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14 Cards in this Set
- Front
- Back
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DOC for uncomplicated E. coli w/ no resistance?
Recurrent UTI's? DOC for resistant E. coli? DOC for pyelo/prostatis? DOC for hospitalized pts? |
Bactrim
F, Amox/Clav, 3G cephalosporin Cipro, nitrofurantoin, cephalosporin Cipro Ceftriaxone, F, Ticar/clav, imipen, maybe AG |
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Nitrofurantoin:
Indications: MOA? ROA? Excreted? ADR's? OK for kids or not? |
Indications: simple UTI, G-, not pyelo
MOA - interferes w/ metabolism ROA - oral, with food or milk excreted in urine ADR - pulmonary, maybe PERMANENT, hemolysis, hepatic, neuro Ok for >6 wks, avoid neonates,pregnancy |
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Associated with Stevens-Johnson syndrome:
Indications: Protein bound - significance? ADR's? interacts with what drug? OK for kids? |
Sulfonamides
simple/complicated UTI's displaces bilirubin --> kernicterus ADR's - SJS, blood dyscrasia, nephrosis, kernicterus interacts with warfarin avoid newborns, OK for kids |
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Fluoroquinolones:
Indications? MOA? excretion? ADR's? Contraindicated for who? DI's? |
Indications: Most UTI's
inhibit DNA topoisomerase II urine ADR - CNS, skin, tendon damage, cartilage damage - contraindicated in pregnancy, children DI - antacids, enhance warfarin |
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Penicillins:
MOA? ROA? ADR's? Which one has Na+/H2O retention? DI's? Safe for kids? |
MOA - inhibit cell wall
ROA - oral, parenteral ADR - allergic rxn, ampicillin rash - ticarcillin = Na/H2O DI's - none significant Safe for kids, pregnancies |
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Cephalosporins:
Used for cystitis due to susceptible organisms: Used for pyelo, other serious infections, sepsis: Recurrent UTI's: |
Cephalexin
Ceftriaxone Cefixime |
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Aminoglycosides:
Indications: MOA? ROA? ASE's? NO! Pregnancy category? |
Indications - serious UTI's, combo therapy
MOA - protein synthesis ROA - parenteral only ASE's - nephro, ototoxicity Pregnancy - Category D (risk/benefit ratio) |
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ASE is red neck syndrome:
Other SE's: NO! DI's? Indications? Contraindicated for _______. Why? |
Vancomycin
nephro/ototoxicity other nephro/ototoxic drugs serious UTI's, septicemia, Staph, Enterococcal infections very young, very old - decreased renal fxn |
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DOC:
68 y/o m, cystitis: 68 y/o m, recurrent UTI: 43 y/o f, simple UTI: 7 y/o f, simple UTI: 22 wks pregnant, UTI: 33 wks pregnant, UTI: |
68 y/o - ampicillin
recurrent - 8 wks Cipro 43 y/o - Bactrim, Cipro 7 y/o - Bactrim, Augmentin, PCN, cephalosporins 22 wks pregnant - Cipro, Bactrim, Keflex, Tet 33 wks pregnant - Cipro, Bactrim |
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Most common, malignant type of RCC:
% of kidney tumors found incidentally: Classic triad of renal tumors: Main paraneoplastic syndrome of RCC: |
clear cell
50-60% flank pain, gross hematuria, palpable abd mass High Ca++ |
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Best imaging for renal cancer:
Change of ____ HU units = malignancy Renal tumor vs renal cyst: bad prognosis: RCC invades IVC, goes to _______. Surgery/chemo/radiation effective? |
CT
12 tumor: non homogeneous, +contrast cyst: homogeneous, no contrast R atrium Surgery - effective chemo/radiation - not effective |
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Types of surgery to treat RCC?
Immunotherapy? |
radical nephrectomy
laparoscopic nephrectomy nephron-sparing surgery cryosurgery RFA - cook the tumor Use IL-2- T cell proliferation |
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#1 risk factor for bladder ca?
More common in what ethnicity? Some hazardous occupations? Indwelling Foley caths = greater risk of _______. Cyclophosphamide by-product, toxic to kidney: |
Smoking
Caucasian > blacks fabric, auto, drill press, leather, mill workers SCC acrolein |
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Most common type of bladder ca:
Most common symptom: Workup? (CCCP) Bladder ca > renal ca in mets to ________. Surgical tx? |
transitional cell (90%)
microscopic/gross hematuria cytology, culture, cystoscopy, pyelography bones Pelvic exenteration - take everything |
