Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
|
tubulointerstitium is composed of
|
vasa recta, tubules, collecting duct
|
|
|
glomerularnephritis vs interstitial disease
|
interstitial disease has:
less proteiniuria ( < 1.5g) no casts saltwasting early (since salt management is tubular job) early anemia don't see hypertension common see acidosis early (since tubules handle acid) |
|
|
drug cause of chronic tubulointersitial nephritis
|
analgesic nephropathy
lithium cis-platinum lead cyclosporine |
|
|
analgesic nephropathy
|
slow progressive chronic renal failure
history of pain syndromes (which causes them to take analgesics) asprin + acetaminophen combintion renal papillary necrosis - flank pain and hematuria see small kidneys with bumby contour and papillary calcification |
|
|
renal papilalry necrosis
|
flank pain
hematuria calcified papillae slough off and pass like a stone can see with analgesic nephropathy, UTI, diabetes, sickle cell |
|
|
myeloma renal disease - chronic TIN
|
light chain deposition
cast nephropathy |
|
|
sickle cell renal disease - chronic TIN
|
renal blood flow blockage -> interstitial nephropathy
|
|
|
things to look out for in chronic tubulointerstitial nephritis
|
keep an eye on drugs
renal insufficiency tubular disfunction (i.e. glucose in urine when there is no diabetes) protein loss is not to nephrotic proprtions anemia not in proprotion of GFR NO hypertension small kidneys (normal is 12cm) no casts |
|
|
acute TIN vs Chronic TIN
|
both are interstitium injury
acute TIN - edema chronic TIN - fibrosis acute TIN - reversible chronic TIN - irreversible |
|
|
acute allergic TIN
|
severe inflam cell infiltrate with intersitial edema - see eosinophils
see tubulitis - inflammation within tubules glomerulus is normal clinically: acute renal insufficiency tubular dysfunction - hyperkalemia, hyperchloremic metabolic acidosis, fanconi syndrome fever, rash, eosinophilia* Causes: drugs - betalactams (penecillin, ampicillin), rifampin, diuretics, NSAIDS treat with steroids, remove offending agent |
