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10 Cards in this Set
- Front
- Back
what secretes renin
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juxtaglomerular cells (granular cells) of the juxtaglomerular apparatus
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juxtraglomerular apparatus is composed of
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juxtraglomerular (granular) cells, magula densa, extraglomerular mesangial cells
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tubuloglomerular feedback
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macula densa senses the high salt and high tubular flow -> reduction of GFR
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does the glomerular capilaries filter by size or charge
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both!
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masuring effective renal plasma flow
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use paraminophippurate (PAH) - which is excreted completely through secretion
RPF = UV/P U = urine concentration of PAH V = urine flow P = plasma conc of PAH |
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measuring GFR
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inulin most accurate but rarely used (inuline is freely filtered but not secreted or reabsorbed)
cleartine clearance close approx - overestimates by 10% due to secretion but can block secretion with probenecid or bactrim or cimetidine if GFR is low the mean of creatinine clearance and urea clearance radionucleotide iothalamate or DTPA |
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creatine clearance eq
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Creatinine clearance =
(140 - age x weight)/(plasma creatinine x 72) multiply this by 0.85 for women |
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bactrim and probenecid or cimetidine
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use to block creatinine secretion
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proximal tubule function
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determined by ability to clear, excrete, reabsorb naturally occuring substances - glucose, AA, phosphate, urate, bicarb, beta2 microglob
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distal tubule function
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determined by renal acidification and urine concentration
if metabolic acidosis (normal AG) and urine AG is negative then NH4+ production and proton secretion is working if AG is positive, distal acidification is impaired |