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10 Cards in this Set

  • Front
  • Back
what secretes renin
juxtaglomerular cells (granular cells) of the juxtaglomerular apparatus
juxtraglomerular apparatus is composed of
juxtraglomerular (granular) cells, magula densa, extraglomerular mesangial cells
tubuloglomerular feedback
macula densa senses the high salt and high tubular flow -> reduction of GFR
does the glomerular capilaries filter by size or charge
both!
masuring effective renal plasma flow
use paraminophippurate (PAH) - which is excreted completely through secretion

RPF = UV/P

U = urine concentration of PAH
V = urine flow
P = plasma conc of PAH
measuring GFR
inulin most accurate but rarely used (inuline is freely filtered but not secreted or reabsorbed)

cleartine clearance close approx - overestimates by 10% due to secretion but can block secretion with probenecid or bactrim or cimetidine

if GFR is low the mean of creatinine clearance and urea clearance

radionucleotide iothalamate or DTPA
creatine clearance eq
Creatinine clearance =
(140 - age x weight)/(plasma creatinine x 72)

multiply this by 0.85 for women
bactrim and probenecid or cimetidine
use to block creatinine secretion
proximal tubule function
determined by ability to clear, excrete, reabsorb naturally occuring substances - glucose, AA, phosphate, urate, bicarb, beta2 microglob
distal tubule function
determined by renal acidification and urine concentration

if metabolic acidosis (normal AG) and urine AG is negative then NH4+ production and proton secretion is working

if AG is positive, distal acidification is impaired