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15 Cards in this Set
- Front
- Back
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3 phases of the immune system |
Recognition Induction Effect |
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What are the 2 basic recognition paradigms |
Self recognition systems Active not self recognition systems |
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What is the self recognition system |
Proposes that cells attack other cells that do not bear the ligand on the cells surface. May nit really exist |
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What is the active not self recognition system? |
Targets the not self ligands and uses either PAMPs or antigens |
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Describe the process of the self recognition system to initiates effector activity. |
Involves the alternative pathway of complement cascade where there is a spontaneous C3 hydrolysis that allows binding of not self to the cell surface. This initiates downstream effector activity and proteins are activated on cell's surface to imitate MAC (membrane attack complex) and cell lysis occurs. |
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What is MAC? |
Membrane attack complex involves in the alternative pathway of the complement cascade that is initiated by activated proteins on the cell's surface and performs cell lysis on not self cells
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How does self molecules avoid this effector activity? |
Self have DAF (decay accelerating factor) that degrades C3 hydrolysis |
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True or false. DAF is involved in the complement cascade |
False. It is not involved in the cascade as a process but prevents the cascade from happening by Degrading C3 to prevents it spontaneous hydrolysis |
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What has been a problem with DAF? |
Pathogens have now been able to mimic the DAF on their cell surfaces so that it can be undetected to undergo the complement cascade of the self recognition system. |
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Natural killer cells are |
A type of lymphocyte that can directly destroy not self cells |
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What allows NK cells to determine whether the ligands on a cell are self or not self? |
They have both activating and inhibitory receptors that allow them to determine this. |
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What encodes the activating and inhibitory receptors on the NK cells |
The major histocompatibility complex (MHC) |
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MHC are found on NK cells. True or false |
True. They encode the activating and inhibitory receptors that fetch self or not self ligands on cells
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If a cell does not express the MHC, are they destroyed by NK cells? |
Yes |
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Name the 2 mechanisms of active not self recognition |
Pattern recognition and specific immunorecognition |
