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28 Cards in this Set
- Front
- Back
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GABA a |
ligand gated calcium channel - ca enters hyperpolarisation nicotinic r like - 5 subunits (2alpha1, 2beta2 1 gamma2)- 4 tmd extraceullar n and c term post synaptic bind 2 gaba |
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nicotinic acetylcholine receptor |
ligand gated non specific cation channel - depolarisation nicotinic r like- 5 subunits (in cns 2xα4 (bind 2 ach) 3xβ2 or 5xα7 homopentamer - 4tmd extracellular n and c term |
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P2Y ATP receptor |
ligand gated non specific cation channel 3 subunits 2 tmd non specific cation |
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NMDA |
(ionotrophic glutamate) ligand gated non specific cation channel (na k ca) 2 Glu N1 2 gluN2 3 tmd, 1 p loop tmd 4 subunits- heterodimer longs n terminus, extrac, c terminus intrac glutamate binds glun2 glyine on n1 |
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cannabinoid |
rhodopsin like GPCR 1 subunit, 7 tmd extracellular n intracellular c |
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muscarinic ach receptor (M1, 3, 5) |
rhodopsin like GPCR- linked to Gq/11 M1dendrites and soma |
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Dopamine 1 family (D1 &D5) |
rhodopsin like GPCR- linked to Gs mainly post synaptic -agonists not clinically active - desensitization |
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5HT 1 (A, B, D) |
rhodopsin like GPCR- linked to Gi/o |
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alpha 1 |
rhodopsin like GPCR- linked to Gq/11 NA>A |
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opioid receptor |
rhodopsin like GPCR |
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GABA b |
metabotrophic glutamate GPCR- linked to Galphai pre- inhibit VGCC post- open K channels |
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mGlu 1 & 5 |
metabotrophic glutamate GPCR LBS on N terminus extracellular C terminus intracellular class 1 - G q 11- PLC- IP3 & DAG- ca and PKC mostly postsynaptic |
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VIP parathyroid |
secretin like GPCR |
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glycine |
Nicotinic R like ligand gated calcium cation channel (alpha 1-4, beta 1) 3/2 alpha, 2/3 beta glycine binds to alpha subunit |
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mGLu 2, 3, (group II) 4, 6, 7, 8, (group III) |
GPCP metabotrophic glutamate long N terminus - LBS intracellular C terminus linked to Galpha i - inhibits cAMP mostly presynaptic |
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Dopamine 2 family (D2, 3, 4) |
Rhodopsin like GPCR- liked to Gi/o |
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alpha 2 NA |
Rhodopsin like GPCR- linked to g i/o A>NA |
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beta 1&2 |
Rhodopsin like GPCR- linked to Gs NA>A, NA=A |
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5HT 3 |
nicotinic like ligand gated cation channel |
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5HT 2 (A, B, C) |
rhodopsin like GCPR- linked to Gq/11 |
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5HT 4, 6, 7 |
rhodopsin like GCPR- linked to Gs |
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5HT 5 |
rhodopsin like GPCR- linked to Gi/o |
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muscarinic Ach receptor (M2,4) |
Rhodopsin like GPCR- linked to G alpha i and o presynaptic |
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NPY |
G protein coupled receptor- linked to gi/o |
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NK1 |
G protein coupled receptor inked to g q/11 |
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TrkA receptor |
intrinsic enzyme receptor- dimer of 2 subunits each with 1 tmd |
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AMPA |
glu a 1-4 (2 of one type 2 of other) only some allow ca through |
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kainate |
glu 1-3 function homo/hetrodimer glu 4 or 5 need to combine with 1 of above only permeable to na |
