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7 Cards in this Set
- Front
- Back
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where do ROS come from?
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mitochondria, NADPH oxidase, peroxidase, oxidase, antioxidants, redox cycling compounds, environmental toxins (smoke)
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some redox compounds are necessary for...
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cell signalling
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MnSOD makes hydrogen peroxide from superoxide in the matrix. Why is this necessary?
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a small amount of hydrogen peroxide is needed for cell signalling. Hydrogen peroxide can cross membranes while superoxide cannot.
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What are some common antioxidants?
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vitamins C and E, glutathione, beta carotene, and ubiquinone.
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what are three damaging effects of ROS?
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DNA damage, protein modification, and lipid peroxidation
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What are three targets of ROS signalling, and what do these molecules do?
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Hif1a: activated by ROS and stimulates angiogenesis in hypoxic conditions
protein phosphatases: ROS deactivate them matrix metalloproteases: ROS activates them by oxidizing disulfide bond. |
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What are the functions of the three NO synthases?
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NOS 1 (n) is for neuronal signalling
NOS 2 (i) is for killing bacteria NOS 3 (e) is for vasodilation |
