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22 Cards in this Set

  • Front
  • Back
3 causes of vascular renal dz
circulating Immune complex
ANCA
non ANCA, non immune complex
general sx's vasculitis
rash, abdominal pain
immune complex vasculitis
(diseases)
Henoch Schonlein
-children
-IgA in mesangium & immune deposits

Cryoglobulinemia
-3 types
-MPGN + LE rash
-aggregate in cold temps
child
skin rash, arthralgia, abdo pain
intest hem, melena
Henoch Schorlein
-IgA in mesangium, circ immune complex
3 types cryoglobulinemia
Type I
- monoclonal IgM
- assoc w/malignancy

II- mixed
-monoclonal IgM (RF)
-polyclonal
-assoc w/Hep C

Type III
-polyclonal
-assoc w/chronic infection or inflammation (eg. SLE)
LM: hypercell, tramtracking, hyaline thrombi

EM: lg subendo deposits
IMFL: varied
Cryoglobulinemia- hypocomplementemia

(looks like MPGN plus hyaline thrombi)
3 hypocomplement diseases
MPGN
Acute Diffuse Proliferative GN(post strep)
cryoglobulinemia
medium vessel vasculitis
polyarteritis nodosa- kussmal
kawasiki- fifths
child
necrotizing vasculitis
fever, conjunctiva, lips/oral mucosa, lymph
Kawasaki (Fith's, Slapped Cheek, parvovirus)

coronary aneurysm
fever, wt loss, malaise, abdo pain,
necrotizing leisiouns of different ages
Kussmaul sign
HTN, HA, myalgia, cutaneous eruptions
polyarteritis nodosa

hep B seropositivity 30%

tx w/corticosteroids
large vessel vasculitis
Giant Cell (temporal arteritis)
Takayasu
older female
unilateral HA, jaw, vision
elevated ESR
Giant Cell Arteritis
("Temporal Arteritis")
elevated ESR
fever, arthritis, night sweats, myalgia, skin nodules, ocular disturbances
weak pulses in UE
Takayasu's arteritis
"pulseless disease"

asian woman in 40's
focal necrotizing vasculitis
granulomas in lung, necrotizing glomerulonephritis
Wegener's
nasal septum, sinusitis, OM, cough, hemoptysis, hematuria
Wegener's

C-ANCA
C-ANCA, hematuria, RBC casts
Wegener's

tx w/cyclophosphamide & corticosteroids
ANCA pos vasculitis's
Wegener's- granuloma in lung (C-ANCA)
Churg Strauss- eos & asthma, grans
Microscopic Polyangiitis- no grans
LM: sclerotic glomeruli, onion skin (thick vessel wall), hyalinosis, no tubules, wrinkled capillary loops
HTNsive nephrosclerosis
gross: thin cortex, atrophic, granular
HTNsive nephrosclerosis
IMFL: IgM & C3 on sclerosis, no immune complex
HTNsive nephrosclerosis
EM: wrinkled basement membrane "shriveled"
HTNsive nephrosclerosis
thrombotic microangiopathy

subendothelial edema

hemolytic anemia (schistocytes)
capillary congestion
malignant nephrosclerosis
-systolic >180
-diastolic >100