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22 Cards in this Set
- Front
- Back
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3 causes of vascular renal dz
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circulating Immune complex
ANCA non ANCA, non immune complex |
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general sx's vasculitis
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rash, abdominal pain
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immune complex vasculitis
(diseases) |
Henoch Schonlein
-children -IgA in mesangium & immune deposits Cryoglobulinemia -3 types -MPGN + LE rash -aggregate in cold temps |
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child
skin rash, arthralgia, abdo pain intest hem, melena |
Henoch Schorlein
-IgA in mesangium, circ immune complex |
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3 types cryoglobulinemia
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Type I
- monoclonal IgM - assoc w/malignancy II- mixed -monoclonal IgM (RF) -polyclonal -assoc w/Hep C Type III -polyclonal -assoc w/chronic infection or inflammation (eg. SLE) |
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LM: hypercell, tramtracking, hyaline thrombi
EM: lg subendo deposits IMFL: varied |
Cryoglobulinemia- hypocomplementemia
(looks like MPGN plus hyaline thrombi) |
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3 hypocomplement diseases
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MPGN
Acute Diffuse Proliferative GN(post strep) cryoglobulinemia |
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medium vessel vasculitis
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polyarteritis nodosa- kussmal
kawasiki- fifths |
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child
necrotizing vasculitis fever, conjunctiva, lips/oral mucosa, lymph |
Kawasaki (Fith's, Slapped Cheek, parvovirus)
coronary aneurysm |
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fever, wt loss, malaise, abdo pain,
necrotizing leisiouns of different ages Kussmaul sign HTN, HA, myalgia, cutaneous eruptions |
polyarteritis nodosa
hep B seropositivity 30% tx w/corticosteroids |
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large vessel vasculitis
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Giant Cell (temporal arteritis)
Takayasu |
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older female
unilateral HA, jaw, vision elevated ESR |
Giant Cell Arteritis
("Temporal Arteritis") |
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elevated ESR
fever, arthritis, night sweats, myalgia, skin nodules, ocular disturbances weak pulses in UE |
Takayasu's arteritis
"pulseless disease" asian woman in 40's |
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focal necrotizing vasculitis
granulomas in lung, necrotizing glomerulonephritis |
Wegener's
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nasal septum, sinusitis, OM, cough, hemoptysis, hematuria
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Wegener's
C-ANCA |
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C-ANCA, hematuria, RBC casts
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Wegener's
tx w/cyclophosphamide & corticosteroids |
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ANCA pos vasculitis's
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Wegener's- granuloma in lung (C-ANCA)
Churg Strauss- eos & asthma, grans Microscopic Polyangiitis- no grans |
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LM: sclerotic glomeruli, onion skin (thick vessel wall), hyalinosis, no tubules, wrinkled capillary loops
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HTNsive nephrosclerosis
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gross: thin cortex, atrophic, granular
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HTNsive nephrosclerosis
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IMFL: IgM & C3 on sclerosis, no immune complex
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HTNsive nephrosclerosis
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EM: wrinkled basement membrane "shriveled"
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HTNsive nephrosclerosis
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thrombotic microangiopathy
subendothelial edema hemolytic anemia (schistocytes) capillary congestion |
malignant nephrosclerosis
-systolic >180 -diastolic >100 |
