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41 Cards in this Set

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  • Back
most important insulin after a meal
pre-formed "granules"

(3 phases: preformed, late, basal)
prediabetic lab results
FBG 100-125
2 hr post parandial 140-199

(same for GTT)
lab results for diabetic
FBG 126 or greater
2 hr post parandial 200 or more
common location for insulinemia
tail of pancreas
(remove 1st)
role of insulin
Storage

(without insulin get musc wasting, no fat or glucose storage
diabetes study results
PIMA's did worse if in US

controlled alone had fewer complications even if bad ctrl later

wt loss "cancelled effect of gene"
window of opportunity
12 years of prediabetic
(usually)
distinguish type I from type II
islet cell Ab test
diabetic complications most related to ...

(lab value)
AI C
Insulin Analogs
Short term
-Lispro
-Insulin

Intermediate
-NPH

Long Term
-Lente
-Ultralente
-Glargine
Lispro
short term insulin
NPH
intermediate insulin
Glargine
Long term insulin
SE's of insulin
Hypoglycemia
(rare hypersensitivity)
Hypoglycemia & rare hypersensitivity
SE's insulin
Affects of Insulin
Tyrosine Kinase activity

Liver: increased glycogen

Muscle:
-increased glyc & prot synth
-increased K uptake
-increased glucose uptake

Fat:
-increased TG storage
Sulfonylureas
First Gen
-Tolbutamide
-Chlorpropamide

Second Gen
-Glyburide
-glimepiride
Tolbutamide
first gen sulfonylurea
Chlopropamide
First gen sulfonylurea
Glyburide
second gen sulfonylurea
Glimepiride
second gen sulfonylurea
MOA sulfonylureas
Close K channel
Prolonged depolarization
release insulin via cAMP
SE's sulfonylureas
First Gen: disulfarim

Second Gen: hypoglycemia
Biguanides
Metformin
MOA biguanides
Decrease GNG
increase glycolysis
decrease serum glucose

(metformin)
SE metformin
Lactic acidosis
(contraindicated in renal dz)
DM med contraindicated in renal dz
Metformin
Glitazones
Pioglitazone
Rosiglitazone
MOA glitazones
(TZD's)
increase target cell response to insulin

(increase tissue receptors)
SE's glitazones
weight gain
edema
hepatotoxicity (triglitizone off market)
DM med with weight gain as SE
glitazones
alpha glucosidase inhibitors
Acarbose
Miglitol
MOA glucosidase inhibitor
inhibit brush border enzyme
SE's Glucosidase inhibitors
yucky
GI disturbance
Amylin analog
Premlinitide
suppress glucagon
premlinitide
amylin analog
(suppress glucagon)
Miglitol
alpha glucosidase inhibitor
GLP agonist
Exenitide
Repaglinidide
Stimulates secretion of insulin in presence of glucose

short t 1/2
stim ins secretion in presence of glucose
repaglinidide
Ezetimibe
NOT DM med!!!
prevents chol absorp