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21 Cards in this Set

  • Front
  • Back
normal urine concentration
total body
body 30-1200 mOsm
cortex 300
medulla 1200
PCT 300
DCT 100
main regulator of total body fluid
concentration/dilation of urine

kidneys can:
-concentrate by 4 fold
-dilute by 10 fold
componants of CCM
-osm balance w/cortex

descending loop
-not perm Na
-lots of water out

ascending loop
-not perm water
-Na, Cl out

vasa recta flow in opposite dir
role of vasa recta
absorb Na & H2O
slow flow
(unless hypervolemic conditions)
affect of increased flow rate in vasa recta
medulla interstitium lower mOsm
ADH is synthesized in...

supraoptic and paraventricular nuclei
regulators of urine concentration
ADH secreted in response to...
high plasma osmolality
low plasma volume
ADH secreted from
posterior pituitary
osmoreceptors for ADH in

sensitized by volume depletion (desens by exp)
set point for osmoreceptors
285-295 mOsm
sharp curve after that
mech of action for ADH
increase expression aquaporin
-V2 R on principal cell (CD)
-GPCR, activate cAMP
-phosphorylate prot in vesicle

cAMP dependent increase reabsorp urea
result of ADH binding in CD
increased aquaporin expression
increased urea reabsorption (out of medullary collecting duct)
affect of COX inhibitors on ADH
PGE2 stimulated by ADH
blunts antidiuresis

COX inhibitors enhance ADH water resoprtion
urea filtration/reabsorption characteristics
freely filtered
passive reabsorbed at PCT
ADH increases reabsorp at Medullary CT
affect of high protein diet on water content of body
increased Urea
increased osmotic drive water out into medulla
thirst stimulated by
increased plasma osmolality
decreased plasma volume
increased AT II
dry mouth (independent of body solute)

decrease stim w/gastric distention
free water
measurement of difference from isoosmotic urine

CH2O = V - Cosm
(Cosm = GFR)
hypoosmotic urine,
pos or neg CH2O
positive- water excreted
hyperosmotic urine,
pos or neg CH2O
negative- water conserved
thirst osmorerecptors activate
Na appetite (activates RAS)