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5 Cards in this Set
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TTP associations
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neuro-- confusuion and seizures
fever intravasc hemolysis with fragmented cells- shhistocytes thrombocytopenia more in adults renal insufuciency |
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what is differennt between TTP and HUS
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differ version of same disease
HUS is mostly in kids after E coli 0157:H7 TTP is assoc with ticlopedin clopidogrel cyclosporine and AIDS |
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what is in HUS
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neuro-- confusuion and seizures
fever intravasc hemolysis with fragmented cells- shistocytes reticulocytes increased bilirubin, decreased haptoglobin thrombocytopenia renal insufuciency |
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lab tests
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normal PT/PTT
coombs test (-) |
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tx
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plasma pheresis or plasma exchange daily is first line until better
no platelets transfusion!! if delay in plasma pheresis-- do FFP add steroids if etiology is NOT to drug induced and / or TTp recurs despite plasma exchange recurrent or refractory PPT-HUS- plasma exchange 2 times daily+cyclosporine or rituximab |
