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14 Cards in this Set

  • Front
  • Back
differentiate 2 types of polycythemia rubra vera
relative( decre plasma volume0
absol ( increaesd RBC)
measureRBC mass with CR labeled RBC and plasma volume with 125 I allbumin
normal RBC in man- 30(+-)3 ml/kg
woman 27(+-) 2 ml/kg
relative polycethemia alsoa called
stress polycythemia
GAISBOCK SYNDROME
RELATIVE CAUSE BY
DEHYDR
ds relative polycethemia
hypertensive smoking middle age man
symptoms relative polycethemia
risk of incre thrombosis
pathology in relaibe polycythemia
smok and diuretics
tx
stop smok
phleb
use non diuretics antihypertes
absolute polycythemia may be
p secondary or primary
secondary polycythemia 2 types
1physiologically appropriate responce to tissue hypoxia
will be increased EPO
2 physiologicall inappropriate responcew to tissue hypoxia
secondary polycythemia physiologically appropriate responce to tissue hypoxia
seen in
1)high altitude ( ds- increased AP diameter of chest
ruddy cyanosis
engorg capillaries of skin
mucus membranes
2) cardiopulm diseases-- rightt oleft shunts, COPD
3)alveolar hypoventilation ( pickwickian syndrome)
4) abnormalities of oxygen hemog dissociation curve
high oxygen affinity hemoglobinopathies ,. herediatory meth hemoglobinemias
carbon monoxide exposure( smoking, industrial exposure)
physiological inappropriate response to tissue hypoxia
neoplams an dnon neoplastic renal disease- renal and adrenal cancer
cerebellar hemangioblastoma
hepatocellular carcinoma

non neopastic: renal cysts and hydronephrosis
increased epo production
2 drug induced-- testosterone
adrenal cortocisterois
symptoms of physiologicall inappropriate response to tissue hypoxia
ruddy cyanosis
head ache
tinnitus
fullness in head and neck
diziness
increased thrombotic events
epistaxis
upper GI bleeding
ds
serum EPO level to evaluate hypoxia
Ct abd
chesxt Xray
BM biopsy with chromos analysis
tx in appropr..
in inappropr...
appr- phlebo... to htc <50
inapp.. phlebo hem, < 60