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14 Cards in this Set
- Front
- Back
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differentiate 2 types of polycythemia rubra vera
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relative( decre plasma volume0
absol ( increaesd RBC) measureRBC mass with CR labeled RBC and plasma volume with 125 I allbumin normal RBC in man- 30(+-)3 ml/kg woman 27(+-) 2 ml/kg |
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relative polycethemia alsoa called
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stress polycythemia
GAISBOCK SYNDROME |
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RELATIVE CAUSE BY
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DEHYDR
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ds relative polycethemia
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hypertensive smoking middle age man
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symptoms relative polycethemia
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risk of incre thrombosis
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pathology in relaibe polycythemia
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smok and diuretics
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tx
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stop smok
phleb use non diuretics antihypertes |
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absolute polycythemia may be
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p secondary or primary
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secondary polycythemia 2 types
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1physiologically appropriate responce to tissue hypoxia
will be increased EPO 2 physiologicall inappropriate responcew to tissue hypoxia |
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secondary polycythemia physiologically appropriate responce to tissue hypoxia
seen in |
1)high altitude ( ds- increased AP diameter of chest
ruddy cyanosis engorg capillaries of skin mucus membranes 2) cardiopulm diseases-- rightt oleft shunts, COPD 3)alveolar hypoventilation ( pickwickian syndrome) 4) abnormalities of oxygen hemog dissociation curve high oxygen affinity hemoglobinopathies ,. herediatory meth hemoglobinemias carbon monoxide exposure( smoking, industrial exposure) |
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physiological inappropriate response to tissue hypoxia
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neoplams an dnon neoplastic renal disease- renal and adrenal cancer
cerebellar hemangioblastoma hepatocellular carcinoma non neopastic: renal cysts and hydronephrosis increased epo production 2 drug induced-- testosterone adrenal cortocisterois |
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symptoms of physiologicall inappropriate response to tissue hypoxia
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ruddy cyanosis
head ache tinnitus fullness in head and neck diziness increased thrombotic events epistaxis upper GI bleeding |
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ds
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serum EPO level to evaluate hypoxia
Ct abd chesxt Xray BM biopsy with chromos analysis |
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tx in appropr..
in inappropr... |
appr- phlebo... to htc <50
inapp.. phlebo hem, < 60 |
