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16 Cards in this Set
- Front
- Back
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Hairy cell leukemia
is a rare malignancy of |
Hairy cell leukemia
is a rare malignancy of B lymphocytes |
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ages
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It is
most common between the ages of 50 and 60 shows a 5:1 male predominance. |
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symptoms
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Patients generally present with the symptoms
of pancytopenia, namely fatigue, easy bruising, and recurrent infection, as well as splenomegaly (and hepatomegaly in 50% of patients). |
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why Mycobacterial infections are common
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Mycobacterial infections are common
due to a striking monocytopenia that is nearly universal in these patients. |
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how often is lymphodenopathy
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rare.
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Examination of the
spleen shows |
Examination of the
spleen shows infiltration of the red pulp by these cells, which demonstrate the characteristic “hairy cell” cytoplasmic projections |
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what lab test
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and are
typically tartrate-resistant acid phosphatase positive. |
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prognosis
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Although patients may demonstrate
markedly abnormal blood counts at presentation, > 90% of patients will live longer than 10 years with treatmen |
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what will be with Hb and thromboc and particular-- monocytes?
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d/d with aplastic anemia
nonhodjkin lymphoma fancomy anemia waldenstrom macroglobulinemia |
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case presentation
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cytoplasmatic projection
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what markers for hairy cell leukemia
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cd11
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MAT
what labs and BM |
MAT- tartrate resistant acid phosphatase ( TRAP) or CD11
BM is dry( cant aspirate) is fibrotic |
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febrile neutropenia
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singe temperature>38 .3 or sustained temperature>38 for more than 1 hour in neutropenic patient
neutropenia is Absolute Neutrophill Count < 500 |
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most common bugs in neutopenia
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gram(-)-- P. aeroginosa
or even gram+ |
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tx
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hospitaliz
empiric antibiotics( covr gram_ ( P aeruginosa!!__ _ceftazidime( 3 generation) or cefepime( 4 generation) cover p aerogin, enterobactericea and many gram+>> will be first choice although Gi has anaerobic, the coverah=ge is not indicated in the initial empiric tx indicated only ifnecrotizin mucositis periodontal abcess perirectal abcess cellulitis. intra abldominal / pelvic infection , typhlitis necrotizing neutropenic colitis or anaerobic bacteremia--->>>> >>>gentamicin and metronidazole |
