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42 Cards in this Set
- Front
- Back
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Incubation period of measles
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14 days
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Intrinsic incubation period of arboviruses
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1 week
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Extrinsic incubation period of arboviruses
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14 days
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Where do arboviruses initially replicate?
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vascular endothelium
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species of mosquito vector in yellow fever
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aedes aegypti
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incubation period of parvovirus B-19
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14 days
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incubation period of rubella
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18 days
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Symptoms of congenital rubella
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cataracts, heart defects, deafness, retardation
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incubation period of HSV-1 and HSV-2
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1-2 weeks
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How long does it take for perinatal HSV to show up after birth?
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6 days
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incubation period of VZV
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2-3 weeks
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symptoms of congenital varicella syndrome
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limb atrophy wiht skin scarring
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incubation period of CMV
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3-12 weeks
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Best treatment for CMV
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ganciclovir
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incubation period of EBV
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4-6 weeks
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action of thymidine kinase drugs
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chain termination
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DNA polymerase inhibitors
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adenine arabinoside, foscarnet
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thymidine kinase drugs
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acyclovir, ganciclovir, trifluoridine
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Treatment for RSV
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aerosolized ribavirin
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treatment for chronic hep c
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alpha interferon + ribavirin
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treatment for chronic hep b
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alpha interferon + lamuvidine
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treatment for influenza a
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amantidine
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treatment for influenza a, b, c
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oseltamivir
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treatment for HSV
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acyclovir
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treatment for HSV keratitis
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trifluridine or acyclovir
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treatment for recurrent VZV
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acyclovir
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treatment for severe CMV
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ganciclovir, foscarnet
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treatmnet for acyclovir-resistant HSV or VZV
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foscarnet
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What does E6 bind to?
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p53
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what does E7 bind to?
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Rb
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is integration of EBV genes or hepatitis c genes necessary for cell transformation?
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No
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gag encodes?
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nucleocapsid and capsid proteins
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pol encodes?
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reverse transcriptase and integrase
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env encodes?
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envelop glycoproteins
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What are the regulatory genes present in HIV that are not present in other retroviruses?
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TAR, VIF, VPU, REV, NEF
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What are the necessary interactions in HIV entry into cell?
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gp140 with CD4 and chemokine receptor
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What does gp41 do?
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mediates fusion of envelope with membrane
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What are the opportunistic viruses associated with AIDS?
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VZV, EBV, HSV, CMV, HPV, KSAH
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How do nucleoside analog reverse transcriptase inhibitors work?
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chain terminators
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What do protease inhibitors prevent?
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cleavage of gag-pol polypeptide--no assembly and release
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What does AIDS triple cocktail include?
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protease inhibitor, 2 anti-RT inhibitors
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What does Fuzeon bind to?
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gp41
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