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11 Cards in this Set
- Front
- Back
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Name 3 ways to transmit a signal in the Nucleus? |
Small G-proteins Ras Map Kinase Pathways |
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What is does the Scr family kinase consist of? |
Blk Fyn Lyn |
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What do Blk, Fyn and Lyn do? |
They phosphorylate tyrosine on residues Ig-a and Ig-B |
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Name 4 things found on a B-cell receptor structure? |
Membrane bound Ig-M 2 additional chains ITAMS Scr Family Kinase |
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Which protein chains are need from a minimal signaling response on T-cell receptor? |
2 Episilon 1 Delta 1 Gamma |
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Which protein chains are need from a maximal signaling response on T-cell receptor? |
2 Episilon 1 Delta 1 Gamma 2 Zeta |
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How do you initiate a signal response from a T-cell receptor? |
Tyrosine phosphorylation |
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How doe the Syk kinase get activated in the B cells? |
The Blk, Fyn and Lyn activates the syk kinase when the tyrosine is doublely phosphorylated |
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What does Lck do in T cells? |
Lck phosphorylates the ITAMS when the ligand binds to the receptor |
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How is the T-cell activated? |
The ZAP-70 will bind to the phosphorylated zeta chain of the ITAM |
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What is the function of CD45? |
Has a phosphatase that removes the phosphate group from the scr kinase so that it can be activated |
