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11 Cards in this Set
- Front
- Back
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lynch syndrom (hereditary nonpolyposis colon cancer) is AD dz caused by defective |
DNA nucleotide mismatch repair error |
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if 50% of hemoglobin is bounded by oxygen (p50). this increases affinity of hemoglobin for oxygen (left shift). so low tissue oxygen levels stimulate the kidney to increase what |
erythropoietin synthesis which results in a compensatory erythrocytosis, which helps to maintain normal oxygen delivery |
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hyperosmotic volume contraction ocurrs |
loss of fee water exceeds the loss of electoytes, resulting in increased osmolarity and contracted volumes in the ICF and ECF compartments diabetes insipidus profuse sweating (hypotonic sweat) |
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acute gastrointestinal hemorrhage (or diarrhea) |
isotonic loss of ecf volume, with no effects on osmolarity or icf |
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adrenal insufficiency |
hypertonic loss of nacl with some extracellular voulme loss (hyposomotic volume contraciton) low osmolarity of the ecf results in shifting of free water into the icf compartments causing icf expansion |
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primary polydipsia |
expanison of both ecf and icf compartments and a decrease in the osmolarity of both compartments (hyposmotic volume expansio) another example is SIADH |
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short non-coding RNA seq (mircoRNA and small intefering RNA) induce posttranscriptional gene silencing by base pairing with complementary seq within target |
mRNA molecules |
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after 12-18hr what process is activated to maintain glucose |
gluconeogenesis-->pyruvate to oxaloacetate, oxa-poshphoenolpyruvate by pyruvate carboxylase and pep carboxykinase |
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elastin-associated glycoprotein that is abundant tin the zonular fibers of the lens, periosteum, and the aortic media |
marfans syn |
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there disulfide-rich globular domains within a purified sample of mature collagen fibrils. what stage of collagen syn is impaired |
extracellular protein cleavage ehlers-danlos syn |
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what is the problem with HbS |
contain valine in place of glutamic acid at the sixth aa position of the Bglobin chain. which promotes hydrophobic interaciton among Hb molecules and results in HbS polymerization and erythrocyte sickling |
