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35 Cards in this Set
- Front
- Back
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catecholamines, serotonin, thyroxine are chmical derivatives of...
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amino acids
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TRH is a chemical derivation of...
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tripeptide
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vasopressin, and somatostatin are chemical derivations of
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small peptides
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insulin and parathyroid hormone are chemical derivations of...
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intermediate peptides
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gonadotropins, and TSH are chemical derivations of
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proteins and glycoproteins
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glucocorticoids, mineralocorticoids, androgens, estrogens, and vitamin D are chemical derivatives of...
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cholesterol
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prostaglanins and leukotrienes are chemical derivates of
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fatty acids
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platelet activating factor is a diriviative of
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phospholipids
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adenosine is a chemical derivative of...
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purine
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NO is a chemical derivative of...
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gas
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what type of hormones are transported through the blood bound to trasport proteins which increase the hormone half life
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lipophilic hormones
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which type of hormones bind to receptors located on te plasma membrane
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hydrophilic hormones
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the binding of a lipophilic hormone to a cytosolic receptor generally causes the release of...
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heat shock protein
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once the heat shock protein is released from the lipophilic hormone receptor, the receptor and bound hormone migrate into the nucleus to bind...
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hormone-receptor complex
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nuclear receptors bind to what hormones to induce a conformational change to affect transcription of genes
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thyroid hormone, retinoids, and vitamin D
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binding of hormone to a G protein causes what changes
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allows GTP to bind to alpha subunit, allowing the separating of the alpha-GTP unit and the beta-gamma subunits
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the Gs family of G-proteins ___ anenylyl cyclase and the Gi ____ it
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stimulates/inhibits
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the Gq family of G proteins will stimulate the activity of
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Phospholipase C
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the G12 family of G proteins will affect
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various ion channels
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the binding of insulin to the insulin receptor results in auto-phosphorylation of the receptor on specific ___ residues
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tyrosine
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the phosphorylated receptor catalyzes phosphorylation of tyrosine residues of...
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Insulin Receptor Substrates (IRS 1-4)
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what are some of the hormones that use the Jak/STAT kinase cascade
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Gh, prolactin, erythropoietin, cytokines
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upon hormone binding Jaks phosphorylate the intracellular domains of what residue
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tyrosine
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what is the function of signal transducers and activators of trascription (STATS)
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activate transcription
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what enzyme is responsible for the conversion of ATP to cAMP
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adenylyl cyclase
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cAMP stimmulates the activity of ___ by binding to the regulatory subunits, and releasing the catalytic subunits
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protein kinase A
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what enzyme is responsible for the hydrolysis of cAMP
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phosphodiesterase
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cAMP is able to increase transcription by causing the the phosphorylation of...
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CREB (cAMP response element binding proteins)
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the generation of cGMP is associated with changes in...
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vascular tone
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cGMP stimulates ____ which phosphorylates a number of smooth muscle proteins
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protein kinase G
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hormone binding on the Gq proteins causes the activity of ...
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phospholipase C
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what function does phospholipase C have
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cleave PIP2 into DAG and IP3
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what is the function of IP3
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acts on receptor on ER causing calcium release
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calcium or DAG can affect what type of kinases
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protein kinase C
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what is the name of the calcium dependent regulatory protein
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calmodulin
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