Qbank - 6/26/2012

Front 1

burr cell?

Back 1

milder form of acanthocyte

uremia, pyruvate kinase deficiency, microangiopathic hemolytic anemia, mechanical damage

Front 2

what is danazol? Clomiphene? Medroxyprogesterone? Mifepristone? Flutamide? Finasteride?

Back 2

danazol - synthetic androgen for tx of endometriosis & hereditary angioedema

clomiphene - antiestronge inferfering w/neg feedback on hypothal & pituitary, increases GnRH synth, used for infertility

Medroxyprogesterone - progesterone only contracept, IM q12 wks

Mifepristone - steroid w/anti-progestin & anti-glucocorticoid efects, primarily an abortifacient

flutamide - antiandrogen inhibits binding to testosterone receptor

finasteride - 5alpha reducatase inhibitor

Front 3

E coli that does not ferment sorbitol nor produce glucoronidase?

Back 3

E. coli O157:H7

Front 4

bacteria producing toxins that…

-activate adenylate cyclase?

-activate guanylate cyclase?

-inactivate EF2?

-disrupt cytoskeleton?

Back 4

active adenylate cyclase - b. pertussis (pertussis toxin), B. anthracis (edema factor), ETEC (heat labile), campylobacter, bacillus cerus (heat labile) & v cholera

activate guanylate cyclase - ETEC (heat stable), Yersinia enterocolitica

inactivate EF2 - corynebacterium diphtheriae, Pseudomonas aeruginosa (ADP-ribosylation)

disrupt cytoskeleton - C difficile (toxin B, cytotoxin)

Front 5

drug w/partial agonist & weak antagonist activity at mu receptors?

Back 5

Pentazocine

Front 6

patient with HIV, heroin, or sickle cell dz develops nephrotic syndrome?

Back 6

Focal Segmental Glomerulosclerosis

MC in hispanics & African Americans

Front 7

patient w/lupus gets nephrotic syndrome?

Back 7

Membranous Nephropathy

Front 8

MCC nephrotic syndrome in caucasian adults?

Back 8

Membranous Nephropathy

Front 9

nephrotic syndrome w/hep B, C, or solid tumors?

Back 9

Membranous Nephropathy
or type 1 membranoproliferative (underneath endothelial)

Front 10

Nephrotic syndrome w/some drugs? (NSAIDs, penicillamine)

Back 10

Membranous Nephropathy

Front 11

holosystolic murmur w/thrill? Left sternal border

Back 11

VSD

Front 12

location of immune complex deposition and corresponding glomerulonephropathy?

Back 12

below foot processes, above endothelium - Membranous

within endothelium - Type II emmbranoproliferative (tram track)

below endothelium - Type I membranoproliferative

Front 13

how to think about the 6 nephrotic dz in groups of 2?

Back 13

1st group - foot processes, Minimal Change (kids after infection, associated w/Hodgkins) & focal segmental (HIV, heroin, sickle cell)

Immune complexes - membranous & membranoproliferative

then diabetes & amyloid - diabetes is deposition of hyaline arterosclerosis, get big blebs in certain parts, tx w/ace i
-amyloid get deposits in mesangium, apple green birefringence

Front 14

cola colored urine?

Back 14

Post strept glomerular nephritis

Front 15

transmural inflammation of arterial wall w/fibrinoid necrosis?

Back 15

polyarteritis nodosa (PAN), associated w/hepatitis B in 10-30% cases

this vasculitis can resemble Churg Strauss by histology (the one w/eosinophilia & asthma), but Churg Strauss characteristically has granulomas & eosinophilic necrosis

Front 16

tubocurarine vs succinylcholine?

Back 16

tubocurarine is NON-depolarizing NMJ blockade

Front 17

what drives respiration and where is it sensed?

Back 17

normally CO2 centrally

in prolonged hypercapnia O2 in peripheral chemoreceptors (carotid bodies)

Front 18

what does urine chloride help with?

Back 18

assessing volume status…weird question

Front 19

what is phentolamine? What is phenoxybenzamine?

Back 19

phentolamine - reversible, competitive, non-specific alpha-adrenergic antagonist
-used for catecholaimine induced hypertensive crisis

phenoxybenzamine is a nonselective, irreversible alpha1 & alpha2 receptor antagonist

Front 20

sensory innervation of medial vs lateral forearm?

Back 20

medial - branch of ulnar nn

lateral - branch of musculocutaneous nn