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10 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Glyceryl Trinitrate Pharmacology |
Glyceryl Trinitrate (GTN) is a potent vasodilator that decreases preload by increasing venous capacity, pooling venous blood in the peripheral veins, reducing ventricular filling pressure and decreasing arterial blood pressure (after load). Because of this cascade it also causes vasodilation in coronary arties that are in spasm and may assist the redistributiion of blood flow along collateral channels in the heart. |
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Glyceryl Trinitrate Metabolism |
GTN is readily absorbed and metabolised by the liver |
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Glyceryl Trinitrate Indications |
- Suspected ACS (with pain) - Acute cardiogenic pulmonary oedema - Autonomic dysreflexia (with SBP >160) - Irukandji syndrome (with SBP >160) |
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Glyceryl Trinitrate Contraindications |
- KSAR or hypersensitivity to GTN - Heart rate < 50 OR >150 - SBP <100 - Acute CVA - Head trauma - Phosphodiesterase inhibitor medication administration (e.g. Viagra / Levitra) in last 1/7 |
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Glyceryl Trinitrate Precautions |
- Suspected inferior AMI - Cerebral vascular disease - Risk of hypotension and/or syncope - Intoxication (GTN effects enhanced) - Phosphodiesterase inhibitor medication administration (e.g. Viagra / Levitra) in last 4/7 |
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Glyceryl Trinitrate Side Effects |
- Dizziness - Hypotension - Syncope - Reflex tachycardia - Vascular headaches |
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Glyceryl Trinitrate Presentation |
Spray (sublingual), 400 microg/dose, nitrolingual pump spray |
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Glyceryl Trinitrate Times |
Onset - <2/60 Duration - 20-30/60 Half-life - 5.5/60 |
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Glyceryl Trinitrate Adult Dosages |
SUBLING - 400 microg, repeated at 5/60, no max dose |
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Glyceryl Trinitrate Special Notes |
- GTN is the first line treatment for autonomic dysreflexia, however morphine should be considered as part of the management regime, if the patient is unresponsive to initial treatment. |
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