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21 Cards in this Set

  • Front
  • Back
IMMUNODEFICIENCY
*
AIDS
*
RETROVIRUS
*
ANGIOEDEMA
*
KAPOSI SARCOMA
*
What are characteristics of PRIMARY IMMUNODEFICIENCIES?
1) global
2) selective (only B or T cells affected)
3) cytokine/ cytokine receptor mutations
4) adhesion molecule mutations
5) complement comp mutations
6) mutations of regulators of complement
What are characteristics of SECONDARY IMMUNODEFICIENCIES?
1) it is naturally occurring
2)
a) may get tumors: lymphoma, myeloma, leukemia
b) malnutrition
c) pregnancy
d) infections
e) iatrogenic (chemotherapy or radiation related)
What are 6 PRIMARY IMMUNODEFICIENCIES?
1) X- LINKED GAMMAGLOBULIN
2) COMMON VARIABLE IMMUNODEFICIENCY
3) HYPER IgM SYNDROME
4) DiGEORGE SYNDROME
5) SCID
6) COMPLEMENT OR COMPLEMENT REGULATOR PROBLEMS
1) X- LINKED GAMMAGLOBULIN
failure of B cells to dev

btk mutations

X- linked, mostly found in males

probs in early childhood: viral infections, girardia, arthritis
2) COMMON VARIABLE IMMUNODEFICIENCY
a heterogenous group of disorders

all Ab classes involved

B cell dev defects

URIs, pulmonary, herpetic, and Giardia infectons

afflicts of both sexes, onset in later childhood, adolescence

high freq of AI disease dev
3) HYPER IgM SYNDROME
T cell disorder

Isotype switching

abnormal CD40/ CD154 interactions

x- linked and autosomal isoforms
4) DiGEORGE SYNDROME
an embryonic malformation of pharyngeal pouches 3 and 4

thymus and parathyroids fail to develop

severe t cell deficiency

tetany due to Ca ++ dysregulation

unidentified gene on chromosome 22

partial Di Geroge syndrome exists, and is self- correcting
5) SCID
both b and t cell limbs of the IS absent

immunological problems from birth (graves and candida infections)

most commond form is x- linked, more males affected

autosomal infections (ADA, adenosine deaminase deficiency)
6) COMPLEMENT OR COMPLEMENT REGULATOR PROBLEMS
hereditary angioedema: C1 inhibitory deficiency
What cause SECONDARY IMMUNODEFICIENCIES?
1) Certain neoplasms that displace the IS
2) Iatrogenic (physician caused) form anti-neoplastic medications
KNOW GENETIC INFO!! SEE SLIDES
SEE SLIDES ON INFO ON AIDS!!
What is a RETROVIRUS?
Retroviruses have ds RNA
What is the genome for HIV?
GENOME:
What is the epidemiology?
1) Risk factors:

2) Current incidence USA and world:

3) Pediatric vs Adult incidence:
Pathogenesis of AIDS?

How do cells get infected?

Replication steps?

Cell- cell spread?

Mac transport?

Transformation of HIV to AIDS?
*
Characteristics of AIDS syndrome?
Opportunistic infections:

1) Kaposi's sarcoma

2) CNS lymphoma

3) CNS second target organ beyond the IS