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6 Cards in this Set
- Front
- Back
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What are the 4 major fates of Pyruvate?
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1. alanine
2. latate 3. acetyl coa 4. oxaolacetate |
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Alanine Amino Transferase (ALT)
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pyruvate + NH3 + NADH -> L-alanine + NAD
uses PLP as coenzyme cytosolic reversible |
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Lactate Dehydrogenase (LDH)
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cytosolic, reversible
direct transfer of hydride btwn NAD & pyruvate stereospecific rxn arg and his |
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Pyruvate Dehydrogenase Complex
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mito matrix irreversible
E1 - TPP E2 - lipoamide E3- FAD |
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Accomplishment of PDH complex (3)
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1. pyruvate -> acetyl coA
2. E caputured as NADH & thioester of coA 3. tightly reg by product inhibition |
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Pyruvate Carboxylase
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biotin dependent, mito matrix, irreversible, liver & kidney
1. HCO3 added (ATP) to biotin 2. transfer of CO2 to C3 of pyruvate -> OAA |
