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6 Cards in this Set

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What are the 4 major fates of Pyruvate?
1. alanine
2. latate
3. acetyl coa
4. oxaolacetate
Alanine Amino Transferase (ALT)
pyruvate + NH3 + NADH -> L-alanine + NAD
uses PLP as coenzyme
cytosolic
reversible
Lactate Dehydrogenase (LDH)
cytosolic, reversible
direct transfer of hydride btwn NAD & pyruvate
stereospecific rxn
arg and his
Pyruvate Dehydrogenase Complex
mito matrix irreversible
E1 - TPP
E2 - lipoamide
E3- FAD
Accomplishment of PDH complex (3)
1. pyruvate -> acetyl coA
2. E caputured as NADH & thioester of coA
3. tightly reg by product inhibition
Pyruvate Carboxylase
biotin dependent, mito matrix, irreversible, liver & kidney
1. HCO3 added (ATP) to biotin
2. transfer of CO2 to C3 of pyruvate -> OAA