Pyridoxine B6 & B12

Front 1

Vitamin B6 was isolated by

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Khun & Szent-Gyoryi

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RDA for B6

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1.3mg/day

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How many forms of B6 are ther

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6

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Stablest of the B6 compounds mainly found in animal foods

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Pyridoxine

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Main B6 forms found in plant foods

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Pyridoxal and Pyridoxamine

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Absorption of B6 requires

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dephosphorylation

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_____ at the brush border remove phosphate groups for absorption of B6

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Phosphotases

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B6 is absorbed into the liver via what transport at physiological conditions

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Passive diffusion

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Main organ that takes up B6

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Liver

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Main form of B6 in the blood that binds to albumin

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PLP

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Only unphosphorylated vitamers can be taken up by the

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Tissues

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Most of B6 is stored in what?

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Muscle

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Coenzyme form of B6

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PLP

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______ prevents the diffusion of the vitamin out of the cells

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Phosphorylation

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What prevents dephosphorylation of B6 forms?

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Binding to proteins in circulation

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Involved in A.A. metab and formation of Schiff base

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PLP

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Formation of double bond between N and C

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Schiff base

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All forms of B6 are metabolized to this form

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PLP

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Transfers of an amino group from one A.A. to an alpha-keto acid

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Transamination

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Removal of amino group

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Deamination

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Common end product of deamination

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ammonia

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Removal of carboxyl group from A.A. or molecule, important for neurotransmitter syn

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Decarboxylation

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Last vitamin discovered and first natural compound containing cobalt

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Colbalamin/B12

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Vit 12 is not produced by plants or animals it is produced by

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bacteria

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Cobalamin is the generic term for group of compounds with corrin nucleus called

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corrinoids

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Only two forms active as B12 coenzymes

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Adenosylcobalamin

Methylcobalamin

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True or false: B12 absorption does not require digestion for absorption

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False

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_____ & ___ release cobalamins from polypeptides in the stomach

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Pepsin and HCL

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Found in saliva and gastric juice, binds to vitamin and protect from bacterial use

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R Proteins

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B12 is excreted in

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Bile

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B12- __ complex is needed to be absorbed in the SI by the ileum

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IF

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B12-IF binds to a ____ not a transporter at physiological doses

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Receptor

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High doses of B12 are absorbed by

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Passive diffusion

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B12-IF complex enter the cell via

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Receptor mediated endocytosis

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Protein receptor also known as IF receptor or cubam

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Cubillins

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Circulating storage form transcobalamin

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TCI

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Carries newly absorbed cobalamin to tissues

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TCII

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Delivery from peripheral tissues to liver

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TCIII

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Main storage form in tissues of B12

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Adenosylcobalamine

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Main storage form of B12 in blood

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Methycobalamine