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11 Cards in this Set
- Front
- Back
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What is the pathophysiology of ARDS?
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severe lung inflammation, neutrophil influx, endothelial and epithelial injury, increased permeability pulmonary edema, hyaline membranes
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What is the clinical presentation of ARDS?
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hypoxemia, decreased lung compliance, bilateral infiltartes, systemic inflammatory response with multi-organ failure, abnormal coagulation and fibrinolysis
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What causes injury in ARDS?
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oxidant-mediated injury, cytokine mediated inflammation/injury, neutrophil mediated injury, proteases, ventilator-induced injury, fibrin deposition, fibrosing alveolitis
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What are the common causes of ARDS via direct lung injury?
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pneumonia, aspiration of gastric contents
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What are the common causes of ARDS via indirect lung injury?
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sepsis, severe trauma with shock and multiple transfusions
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What is the most common cause of ARDS?
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severe sepsis
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How do you diagnose ARDS?
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acute onset of bilateral infiltrates like pulmonary edema, no evidence of left heart failure, hypoxemia
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What is the paO2/FiO2 in ARDS?
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< 200
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What works for ARDS?
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low tidal volume, fluid restriction
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What is the downside to low tidal volume?
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sedation, paralytics, acidosis, hemodynamics
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Why do you do fluid restriction in ARDS?
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pulmonary edema is common, increased microvascular pressure will increase pulmonary edema across leaky alveolar capillary barrier, fluid restriction will lower microvascular pressure
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