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15 Cards in this Set
- Front
- Back
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Hormonal Regulators
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PTH
Tereparatide Cholecalciferol Ergocalciferol Calcitriol Paricalcitol |
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2ndary hormone regulators
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Calcitonin
Estrogens Raloxifene |
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Bisphosphonates
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Alendronate
Pamidronate Risedronate Ibandronate Zoledronate MOA - --| enzyme of mevalonate path that are imp for osteoclast fxn and survival -> osteoclast apop -> bone resorption Uses - severe hypercalcemia, Paget's, osteoporosis, hypercalcemia of malignancy AE - esophageal and gastric irritation, necrosis of jaw CI - GERD, PUD |
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Ergocalciferol (Vit D2) - food
Cholecalciferol (Vit D3) - UV radiation |
form of Vitamin D
USES: rickets and osteomalacia MOA: converted in liver to inactive form --> again converted in kidney to active form of Vit D SE: Vit D toxicity --> resembles hypercalcemia |
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Calcitriol
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- Primary therapeutic use for calcitriol is during renal failure when the body can’t produce calcitriol, the agonist for the VDR (renal osteodystrophy)
- also Tx's hypoparathyroidism SE: HYPERcalcemia! no feedback system |
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Paricalcitol
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Vit D analog (dec PTH syn but not inc intestinal Ca absorption in 2ndary hyperPTism due to chronic renal failure)
USES: renal osteodystrophy; produce non-hypercalcemic effects (prostate cancer, psoriasis) |
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Teriparatide
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Used to promote bone formation in severe osteoporosis
- PTH analog USES - Advanced osteoporosis when bisphosphonates Tx fail BLACK BOX - osteosarcoma |
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Calcitonin
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- inhibits osteoclastic activity via direct suppression of osteoclastic activity
USES: PAget's disease, hypercalcemia, osteoporosis, analgesic SE: nausea, flushing, allergic rxns, rhinitis, epitaxis |
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Estrogens
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effectively prevent bone loss
AE - long term use not recommended; inc breast cancer and thromboembolic events |
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Raloxifene
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SERM
has estrogenic effects but antag on breast and uterine receptors AE - hot flash |
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Cinacalcet
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- Ca-sensing receptor (CaSR) activator
- allosteric modulation of the Ca receptor enhances response to Ca2+ - Decrease PTH USES: primary hyperPTism SE: HYPOcalcemia |
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Fluoride
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MOA - accumulation of bone and teeth; stim bone formation by osteoblast
USE - prevention of dental caries in kids AE - arthritis, mottled enamel |
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Calcium
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AE - GI upset, gas, constipation, renal stones
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Phosphate
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facilitated by Vit D and PTH hormone
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Sevelamer
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MOA - binds PO4- preventing absorption and dec serum PO4-
Uses - renal osteodystrophy, pts with renal failure on dialysis, hyperphosphatemia AE - N/V/D, dyspepsia |
