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18 Cards in this Set
- Front
- Back
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What is are angioblasts? Stage of healing?
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endothelial cells that makes up blood vessel walls, adjacent to the zone of injury that bud and grow into affected area
(think granulation tissue) |
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What are chemotactic agents? What stage of healing are the most involved in?
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substances that attract cells necessary for wound repair to the site
(think inflammation -- phagocytosis and debridement) |
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What is chemotaxis?
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movement of cells along a chemical gradient toward the area of injury where the gradient is the highest
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What are cytokines?
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interleukin-1 and TNF-alpha are signaling proteins during the inflammatory phase
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What are fibroblasts?
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the main cells in the dermis,
produce collagen and elastin fibers that give dermis its characteristic strength and flexibility |
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What is galvanotaxis?
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stimulation of cells to move along an electric gradient
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What are growth factors?
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endogenously produced hormone-like substances that control cell growth/size, differentiation, and metabolism
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What are keratinocytes? Phase of healing?
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continuously dividing cells that produce the protective protein keratin (stratum basale)
(think re-epithelialization) |
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What are Langerhan's cells?
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in the deepest layer of the epidermis that help fight infections by attacking and engulfing the foreign substances
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What are macrophages?
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help fight infection by engulfing harmful substances and releasing destructive enzymes
direct repair processes assist with killing bacteria and wound cleaning secretes growth factors and MMPs |
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What are mast cells?
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specialized secretory cells in the dermis
produce chemical mediators of inflammation (histamine) that cause the vessels to vasodilate increased vessel permeability attract other cells to the area to help fight infection or repair injury |
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MMPs (Matrix Metalloproteases)
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proteases produced by various cells during the wound healing process
-neutrophils -macrophages -fibroblasts -keratinocytes they degrade the ECM |
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What are melanocytes?
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produce pigment melanin which protects the skin from harmful effects of UV radiation from the sun and gives theq skin its color
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What are Merkel cells?
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specialized mechanoreceptors that provide information on light touch sensation
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What are myofibroblasts?
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similar properties to smooth muscle cells and fibroblasts
the driving force of wound contraction that pulls the wound margins together |
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What are platelets?
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they form the plug (NOT clot) to control bleeding
secrete growth factors and chemotactic agents |
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What are polymorphonuclear neutrophils (PMNs)?
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circulating WBCs that travel in the capillaries and arterioles, get pushed to the sides of the vessel (margination)
- first cells to injury site - scavengers that kill bacteria (directly through enzymes and also through phagocytosis) - cleans the wound - secretes inflammatory mediators and MMPs |
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What are prostaglandins?
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released by injured cells to induce a longer lasting vasodilation
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