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15 Cards in this Set

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Depolarization
1. resting state is -70
2. NA+ into cell leads to positive charge=-60, cell gets excited (membrane altered) and fires
3. this is action potential=firing = NT release.(glutemate)
4. Excitatory
hyperpolarization
1. CL- goes into cell, inhibitory, cell goes fr0m -70 to -90, will not fires. GABA (barbs)
Synapses kinds
excitatory and inhibitory
GABA
inhibitory, in 75-90 percent of brain cells
Glutemate
Excitatory in 75-90 percent of brain cells
5HT
Indole amine, from trypotophan makes you feel good, in 10 percent of brain cells
NE and DA
Catecholamines, from Tyrosine to L dopa to Dopa to DA to NE.
ACh
REsponsible for anticholinergic side effects caused by tricylics and antipsycotics (conventional)
Reuptake
NT is removed right after it exerts its effect on post synaptic membrane. Reuptake transport pump removes and deactinvates. Most common method of deactivating.
SSRI's
Prozac paxil, zoloft. (also lexapro and celexa)--sexual side effects, decrease orgasm decrease drive,(headache, sleepy, nervous)
SNRI's
1. NRI--walbuterin/zyban-no sexual side effect
2. SNRI-Effexor, Remrone and SEzone (cymbalta)
In low doses affect 5ht, middle doses 5HT and NE high doses also DA.
Seraotonin-why not prescribed
does not ex the Blood Brain Barrier.
Prozac
5 day half life, not a big problem to miss one, arousing give to letghargic patient
Zoloft
12 hour half life, can't miss a dose but can give drug holiday, arousing, give to lethargic patient
Paxil
Sedating, give to imsomniac patient