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10 Cards in this Set
- Front
- Back
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Adverse Effects of ANTIPSYCHOTIC DRUGS? |
Muscarinic Block: Cycloplegia, dry mouth, urinary retention, constipation Dopamine-receptor Block: Parkinsonism (EPS), Tardive Dyskinesia, Amenorrhea, Galactorrhea Metab.: Weight Gain CVS: Torsade & orth. hypo. |
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Pharmacodynamics of Antipsychotic Drugs? |
Efficacy via D2 blockade
Adverse effect includes alpha adrenoreceptors, muscarinic, H1, and 5-HT2 block |
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Describe Mode of Action via D2 block |
Antipsychotic effect in MESOLIMBIC Pathway Extrapyramidal symptoms in NIGROSTRIATAL Pathway Increased Prolactin in TUBEROINFUNDIBULAR Pathway |
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Describe Mode of Action via 5-HT2A block |
5-HT2A stops dopamine release Block 5-HT2A to release dopamine (reduce EPS)
Reduce + & - symptoms in MESOCORTICAL Pathway |
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Typical/Classical Antipsychotics |
D2 antagonists: Chlorprom azine Thiori dazine Fluphe nazine Perphe nazine Trifluope razine Haloperidol |
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Atypical/New Generation Antipsychotics |
Mixed D2/HT Antagonist: Clo zapine Olan zepine Que tiapine Ase napine Rispe ridone Zipra sidone Palipe ridone Sertindone Amisulpride
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Partial agonist of D2 |
Aripiprazole |
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What is Tardive dyskinesia? |
Late occurring syndrome of abnormal choreoathetoid movements (ie. involuntary movement of the face & jaw)
Caused by supersensitivity of dopamine receptors causing relative cholinergic deficiency |
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What is akathisia? |
state of agitation, stress, & restlessness. A common side effect |
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What is akathisia? |
state of agitation, stress, & restlessness. A common side effect |
