Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/72

Click to flip

72 Cards in this Set

  • Front
  • Back
Tx for etoh withdrawl?
benzos
Tx for anorexia/bulimia?
SSRIs
Tx for anxiety?
benzos, barbs, buspirone, maois
Tx for atypical depression?
maoi's
Tx for bipolar d/o?
lithium, valproic acid, carbamazepines
Tx for depress?
SSRIs, TCAs
Tx for depress w/insomnia?
trazodone, mirtazapine
Tx for OCD?
SSRIs
Tx for panic d/o?
TCAs, buspirone
Tx for schizophrenia?
antipsychotics
list antipsychotics
thioridazine, haloperidol, fluphenazine, chlorpromazine
low potency antipsychotics:
thioridazine, chlorpromazine
high potency antipsychotics:
haloperidol, fluphenazine
antipsychotic mech of action?
block D2 (DA) receptors
clinical use of antipsychotics?
schizophrenia, psychosis, acute mania, tourettes
Antipsychotic side effects?
extrapyramidal system (EPS) SEs, endocrine SEs (eg hyperprolac -> amenor, galactor, infertility), muscarinic blockade (dry mouth, constipation, blurred vision, urinary reten), alpha blockade (hypotens), histamine blockade (sedation), neuroleptic malignant syndrome, tardive dyskinesia
which side effects are predominant for low potency antipsychotics?
non-EPS SEs
which SEs predominate for high potency antipsychotics?
EPS SEs
what drugs can cause neuroleptic malignant syndrome?
antipsychotics
what is neuroleptic malignant syndrome?
rigidity, myoglobinuria, ANS instability, hyperpyrexia
what is used to treat neuroleptic malignant syndrome?
dantrolene (and other DA agonists)
what is tardive dyskinesia?
sterotypic oral-facial mvts probably due to DA receptor sensitization; results of long term antipsychotic use
how do EPS SEs progress over time?
4 h - acute dystonia
4 d - akinesia
4 wk - akathisia
4 mo - tardive dyskinesia
name atypical antipsychotics
clozapine, olanzapine, risperidone
atypical antipsychotic MoA?
block 5-HT2 receptors
clinical use of atypical antipsychotics?
schizophrenia, tx neg AND POS sx (typicals tx neg sx only)
additional uses of olanzapine?
OCD, anx d/o, dep, mania, tourettes
atypical antipsychotic SEs?
less severe EPS SEs than high pot drugs, less severe musc/hist/alpha SEs than low pot drugs
important SE of clozapine specifically?
AGRANULOCYTOSIS IN 3%
what type of drug requires weekly WBC monitoring?
CLOZAPINE
LITHIUM MoA?
unknown, maybe related to phosphoinositol cascade
clinical use of LITHIUM?
mood stabilizer for bipolar affective d/o's; blocks relapse and acute manic events
LITHIUM SEs?
tremor, hyperactivity, hyperreflexia, hypothyroidism, polyuria (diabetes insipidus), teratogenesis, c/i w/preg, leukocytosis
what psychiatric drug may be used to treat SIADH?
LITHIUM = ADH antag, causing nephrogenic diabetes insipidus
MoA of BUSPIRONE?
stim' 5HT-1A receptors
clinical use of BUSPIRONE?
relatively pure anxiolysis for GAD
advantage of BUSPIRONE over BENZOs/other anxiolytics?
no sedation or addiction, no additive effects with etoh
name SSRIs
FLUOXETINE, SERTRALINE, PAROXETINE, CITALOPRAM
clinical uses of SSRIs
MDD, OCD(fluoxetine)
SSRI SEs?
GI disress, sexual dysfn (anorgasmia), "serotonin syndrome" w/MAOIs

mild antichol, anti-alpha-1 SEs
sx of serotonin syndrome (SSRIs + MAOIs)?
hyperthermia, muscle rigidity, cardiovasc collapse, change in MS)
name TCAs
IMIPRAMINE, NORTRIPTYLINE, AMITRIPTYLINE, DESIPRAMINE, CLOMIPRAMINE, DOXEPIN
MoA of TCAs?
block reuptake of NE and 5HT
clinical use of TCAs
MDD, bedwetting (imipramine), OCD (clomipramine)
rx for bedwetting (enuresis)?
IMIPRAMINE
what TCA is used for OCD?
CLOMIPRAMINE
SEs of TCAs?
sedation (worse for tert amines), antichol (blurred vis, dry mouth, urin reten, constip, agitation, tachy, sweat), alpha-1 block (postural hypotens, tachy)
name secondary amines
desipramine, nortriptyline
name tertiary amines
imipramine, amitriptyline, doxepin, clomipramine
difference in SEs b/t sec and tert amines?
sec: LESS sedation, hypotens, antichol, but MORE likely to cause psychosis
how long for TCAs to show clinical effect?
2-8wks
sx of TCA toxicity?
Convulsions, Coma, Cardiotoxicity (arrhyth, QT widening), resp dep, hyperprexia

note: may occur when combined with MAOIs
which TCA is least sedating?
DESIPRAMINE
which TCA is best for elderly pts?
NORTRIPTYLINE, b/c less antichol SEs (others may cause confusion and halluc in elderly)
name MAOIs
PHENELZINE, TRANYLCYPROMINE
MoA of MAOIs
nonselective MAO inhibition (blocks inactivation of NE, 5HT, DA that leak out of storage vesicles), thus inc levels of amine NTs
clinical uses of MAOIs
atypical dep (ie w/psychotic or phobic features), anxiety, hypochondriasis
toxicity of MAOIs
hypertensive crisis w/tyramine ingestion (in wine, cheese, etc) and meperidine; CNS stim
MAOI contraindications?
SSRIs, beta-agonists (to prevent serotonin syndrome)
name heterocyclic antidepressants
BUPROPRION, VENLAFAXINE, MIRTAZAPINE, MAPROTILINE, TRAZODONE
clinical uses of BUPROPRION?
MDD, smoking cessation
SEs of BUPROPRION
stimulant effects (tachy, insomnia), h/a, seizure in bulimics; no sexual SEs
clinical uses of VENLAFAXINE
MDD, GAD
MoA of VENLAFAXINE?
inhib' 5HT, NE, & DA reuptake
toxicity of VENLAFAXINE?
stimulant effects, sedation, mausea, constipation, inc BP
MoA of MIRTAZEPINE?
alpha-2 antag (inc release of NE, 5HT), and potent 5HT2 and 5HT3 ANTAG, thus inc' 5HT1 mediated transmission
toxicity of MIRTAZEPINE?
sedation, inc appetite, weight gain, dry mouth
MoA of MAPROTILINE?
blocks NE reuptake
toxicity of MAPROTILINE?
sedation, orthostatic hypotens
MoA of TRAZADONE?
blocks 5HT reputake
toxicity of TRAZADONE?
sedation, nausea, pripism, postural hypotension
what substances affect plasma lithium levels?
excessive Na intake LOWERS lithium levels; thiazide diuretics INCREASE lithium levels