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68 Cards in this Set
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if fear of EMBARRASSMENT present
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specific (i.e. urinating in public, speaking in public) or general (social interaction) social phobia
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What is the difference b/w OCD and OCPD (P for Personality)?
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in OCPD patient does not recognize the behavior as problematic, i.e. patient is being ego-SYNtonic (vs ego-DYStonic)
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SSRI's and Buspirone are first line treatment for what disorders?
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OCD, PTSD, GAD
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What is the antidote to BZD intoxication?
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Flumazenil
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What can be given for muscle spasm?
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Benzodiazepines
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What is a characteristic symptom of PTSD and for how long should it be present?
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REEXPERIENCING of the traumatic event which should be lasting for >1 month
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What other Rx may be helpful in treating PTSD other than the first line Rx (SSRI and Buspirone)?
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TCAs and MAO-Is
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What are the cognitive deficits in deMEntia (MEmory)?
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Aphasia - ("phage"-eat-mouth-language); Apraxia - inability to perform motor activities; aGNOsia - inability to recOGNize; aMnesia - Mmmemory impairment
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What is intact in deMEntia?
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Clear sensorium, yet inability to plan, organize and abstract, i.e. executive fnx is down
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What does one want to AVOID in a demented patient?
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BZD (-zolam, -zepam and Chordiazepoxide)! as BZDs may worsen disinhibition and confusion
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Where does one most often sees deliRIUM?
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ACUTE occurrence (not gradual) in ICU where patient exhibits deficient sensoRIUM- "WAXING and WANING" of consciousness and cognition
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What type of hallucinations are present in deliRIUM?
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mostly visual and tactile (SEE and TOUCH)
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Name some of the types of a Major Depressive Disorder.
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with Psychotic features (i.e. w/delusions/hallucinations); Postpartum (within 1 month post birth); Atypical (weight gain, hypersomnolence, rejection sensitivity); Seasonal (often in winter, responds well to light therapy); Double depression (MDD + dysthymia)
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What is the time-frame within which Adjustment disorder takes place?
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within 3 months of the stressor and resembles MDD
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What happens if SSRIs (Fluoxetine, Sertraline, Paroxetine, Citalopram, Fluvoxamine) are used with or shortly after (within 5 weeks of use) MAO-Is(Phenelzine and Tranylcypromine)?
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Serotonin SYNDROME- fever, myoclonus (twitching of a muscles), mental status change, cardiovascular collapse.
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Name some of the atypical antidepressants (Heterocyclic Acids) and common side effects.
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Amoxapine, BuPropion (lowers seizure threshold, i.e. not for bulimics); VenLaFaxiNe (diastolic hypertension); MiRTAzaPine (weight gain (Remerone)); TRAzoDONe (priapism)
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What common antidepressants can be used for migrane headaches and chronic pain?
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TCAs: NORtriptyline, DesiPramine, AmitripTyline, ImiPRAmine. Lethal cardiac CONDUCTION arrhythmias!
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What is the MonoAmine compound that is found in wine, cheese, etc and when used together with MAO-Is (Phenelzine and TraNYLcYPromine) can cause hypertensive crisis?
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TYRamine - a naturally occurring monoAMINE compound
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What is a prominent feature in MANIA?
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IRRItability
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What is type II bipolar?
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usu HYPOmanic, i.e. less intense than manic
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What are the MEDS for MANIA?
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Antipsychotics (neuroleptics)- typical and atypical; Mood stabilizers (valproic acid, LAMOTRIgine, CARBAmaZEPine, Lithium); BZD if mania is refractory (ECT possible treatment modality if refractory).
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What is the danger of chronic Li use and Lamotrigine?
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HYPOthyroidism and NEPHrotoxicity and life-threatening RASH (eg Stevens Johnson)
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Common Side Effects of ATYPICAL neuroleptics (Clozapine, Risperidone, Quetapine, Olanzapine, Ziprasidone, Aripiprazole) "Orange Cats Are/R in Quiet Zoo"
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Weight gain, DM2. Yet, currently is the first line Rx for Schitzophrenia. Fewer EPS and anticholinergic SE.
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What is Li toxicity associated with?
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Ataxia, dysarthria and deliRIUM. SE: acne, polyuria, thirst, diabetes insipidus, weight gain, seizures, teratogenicity, HYPOthyroidism
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What 2 psych meds may cause agranulocytosis?
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Valproic acid and Clozapine
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If patient is restless, which is becoming distressing to the patient (AKA-THI-sia), what treatment is offered?
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Lower the neuroleptic and give beta-blocker (propranolol)
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What SE reminds Parkinsonism? And what should you do to treat it?
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DYS-ki-nesia. Give antihcolinergic (benZTroPINE) or AMAntiDINE (dopaminergic agonist). Parkinsonism? Need Dopamine. Suppress Ach.
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What is likely the cause of Tardive Dyskinesia (involuntary movements, especially of the lower face)?
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dopamine receptor sensitization
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What is the treatment for Tardive Dyskinesia?
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D/C or lower neuroleptics, consider switching neuroleptics. Initially with those steps in place Tardive Dyskinesia will likely worsen.
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Define dystonia
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Involuntary muscle contraction or spasm (oculogyric crisis, i.e. rotating or 'fixed' eyeballs; torticollis). Tnx: benZTROpine or diPHENhydramine
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Evolution of EPS
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4hrs- dystonia
4days- Akinesia 4weeks-Akathisia 4months-tardive Dyskinesia |
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Types of Schitzophrenia and prognosis
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Best prognosis- paranoid schitz. Worst- disorganized schitz.
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Examples of negative symptoms in Schitzophrenia
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poor emotional reactivity, flat affect, anhedonia, lack of purposeful movement
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What are the clusters for personality disorders?
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Cluster A, B and C. Weird (paranoid, schizoid, schizotypal), Wild (borderline, histrionic, narcissistic, antisocial), Wimpy (OCD, avoidant, dependent)
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What is the treatment for ADHD?
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Psychostimulants: METHYLPHENIDATE, dextroAMPHETAMINE and Antidepressants: SSRI, BuPropion, noRTIPTYline and alpha2-agonists: Clonidine
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What are the differences b/w Autism and Asperger's?
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Same repetitive activities, behaviors and interests, but without marked language or cognitive delays
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A baby girl shows deterioration in growth, esp head growth, language and coordination AFTER 5 months of age. What is the disorder?
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Rett's disorder
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What are the meds to target symptoms in an AUTISTIC child?
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neuroleptics for agression and SSRIs for stereotyped behavior
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What is Tourette's associated with and how would you pharmaceutically manage it?
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ADHD, OCD and learning disorders. Rx: DA DopAmine receptor ANTAgonists (Haloperidol, pimozine), alpha2 AGOnist (Clonidine). Do not give stimulants, as they'll precipitate tics
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What are CAGE questions?
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Cut down, Annoyed, Guilty, Eye opener in the morning. More than 1 yes? Alcoholism is likely.
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Important injectives for EtOH abusers
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administer thiamine (B1) before glucose, as glucose administration depletes thiamine. It will prevent WERNIKE's encephalopathy (ataxia, ophthalmoplegia, confusion, and impairment of short-term memory)
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Important sings of Anorexia Nervosa
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Mitral valve prolapse, HYPOtension, BRADIcardia, arRHYTHmia, nephroLITHIzasis, stress fractures, PANCYTOpenia, messed up thyroid. High suicidality or medical causes of death (over 10%)
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What sleep meds would you prescribe?
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Trazodone (Desyrel-other antidepressant), diphenhydramine (Benadryl), zolpidem (Ambien) and zaleplon (Sonata)
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When does a Conversion disorder happen?
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It is a somatoform disorder that happens in a close temporal proximity to a stress or intense emotion. Resolves spontaneously
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When does a Somatization disorder happen?
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It is a somatoform disorder that is significant for multiple GI, sexual, neurologic, and pain complaints - different organ systems. Schedule REGULAR short appointments with 1' caregiver.
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Explain Hypochondriasis
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fear of having a serious dz DESPITE reassurance from a doc. Schedule regular appointments
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Explain Pain disorder
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Similar to Conversion, yet often associated with depression. Pain out of proportions and can't be explained. Tnx: PT, psychotherapy, behavioral therapy, TCA and VenLAFAXine
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Differentiate PROJECTION from TRANSFERENCE on examples
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Projection: тетя Надя обвиняет Ольгу в том, что та проституирует. На самом же деле тетя Надя испытывает позор за Анну. Transference: you want to marry a girl that has the qualities of your mother
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Reaction formation
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sad, yet cracking jokes.
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Identification
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a brother is killed in Iraq and his little sister wears his military t-shirt
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Isolation of Affect
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trying not to cry in front of the kids, as they will be traumatized
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REpression
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Subconscious. Too traumatic? Then block it from the memory
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ForMICation- tactile hallucination
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in Alcohol withdrawal or Cocaine intoxication
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Delusion vs Illusion
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in Illusion there is misperception with a stimulus
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MOA of Carbamazepine
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a mood stabilizer that blocks Na channels
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uses of Carbamazepine
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due to effective blockade of fast-acting channels, use for TMJ, acute shooting pain, partial or focal seizures
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What are the Side Effects of Carbamazepine?
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WBC decrease, hepatotoxic, SIADH (drinking but not peeing ->bloated)
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types of Monoamine Oxidase
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MAO-A (inhibitor for anti depression)-> "TIPs": Tranylcypromine, Isocarboxazid, Phenelzine and MAO-B (inhibitor for anti Parkinsonism)->SELEGYLINE
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What is the occurrence of depression as the number of risk factors goes up?
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w/1 risk factor->10%(elderly), 2->50% (elderly in hospital), 3->90%(elderly in nursing home). Normal population -1 to 3 %
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SSRI's. Why are they a DOC in many psychiatric conditions (Eating d/o, OCD, Panic attack, Phobia, PTSD, PMDD i.e.premenstrual depressive d/o)?
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as they are being selective (5-HT i.e. serotonin is up)->less SE. Careful within first 90 days. Risk of suicide
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What is the number one reason of noncompliance in SSRI (fluoxetine, sertraline, luvoxetine, paroxetine, citolopram-newest, escitolopram-newest) treatment?
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most often ANORGASMIA in both men and women (i.e. treatment of premature ejaculation in guys can be considered)
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MOA of TCA (imipramine, amitryptaline, clomipramine, desipramine, nortryptaline, doxepin) and what is the antidote if OD?
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block reuptake of catecholamines i.e. NorEpinephrine, Serotonin; Strongly anticholinergic (constipation, dry mouth, blurred vision, dizziness, and slowing of urination); Block alpha1 i.e. hypotensive SE; Block AV conduction in the heart->arrhythmia. Antidote-> bicarb or other base to pee the acid out
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Describe sleep disturbance in DEPRESSION
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excessive sleepiness, early awakenings. REM becomes shorter in bursts but more frequent, i.e. increase in REM overall (paradoxical, yet the quality of sleep is low due to short individual REM bursts)
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What is the number 1 risk of suicide?
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Hx of previous attempts
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What is the best treatment for grief?
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Empathy -try to understand. Sympathy is different and better in a way b/c you have had same experience. The least you can do is EMPATHIZE.
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What's on Axis I?
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psychiatric d/o "no one or nothing causes"
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What's on Axis II?
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mental retardation, cerebral palsy, PERSONALITY disorders
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Axis III, IV, V?
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medical, social/environmental and global functioning assessment.
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