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7 Cards in this Set
- Front
- Back
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cardiac adverse effect of thioridazine (Mellaril)
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prolongs QTc in a dose-related manner
may increase the risk of sudden death by delaying ventricular repolarization and causing torsades de pointes |
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cardiac adverse effect of clozapine (Clozaril)
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may cause myocarditis (rare)
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psychiatric risk factors for the development of coronary disease
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depression
anxiety type A behavior hostility anger acute mental stress data from Normative Aging Study of 498 men with mean age 60 years: dose-response relationship b/w negative emotions, combo anxiety/depression, and incidence of coronary disease |
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psychiatric risk factor with strongest data for association with coronary disease
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depression
e.g., severe depression 6 months after CABG or persistence of moderate depression predicts increased risk of death at 5 year follow-up |
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can behavior modification reduce cardiac risk factors?
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yes
e.g., group therapy to modify type A behavior patterns resulted in reduced reinfarction and mortality in a 4.5 year study |
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can stress management affect cardiac risk factors?
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yes
e.g., meta-analysis of 23 RCTs showed that "psychosocial treatment" had greater reductions in emotional distress, systolic BP, HR, and blood cholesterol v. controls |
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Define the treatment phases for Major Depressive Disorder
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Acute (6-12 weeks)
Continuation (4-6 months) Maintenance (>1 year) |
