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42 Cards in this Set

  • Front
  • Back
Treatment for:
Disinhibition, slurred speech, ataxia, coma, blackouts
GGT
alcohol intoxication:
- naltrexone
- disulfiram
Treatment for:
tremor, tachycardia, hypertension, malaise, seizures, delirium tremens, tactile hallucinations, agitation
alcohol withdrawal:
- benzodiazepines for DTs
Treatment for:
CNS depression, N/V, constipation, pupillary constriction (pinpoint pupils), seizures
Opioid (heroin, morphine, methadone) intoxication:
- naloxone
- naltrexone
Treatment for:
anxiety, insomnia, sweating, anorexia, piloerection, fever, rhinorrhea, nausea, diarrhea, cramps, yawning
Opioid (heroin, morphine, methadone) withdrawal:
- symptomatic
- methadone
- naloxone + buprenorphine
Treatment for:
respiratory depression due to barbituate intoxication
- symptomatic (increase BP, assisted respiration)
Treatment for:
anxiety, seizures, life-threatening cardiovascular collapse, delirium
Barbituate withdrawal
- symptomatic
Treatment for:
amnesia, ataxia, somnolence, minor respiratory depression, worse with alcohol
Benzodiazepine intoxication
- Flumazenil (competitive GABA antagonist)
anxiety, seizures, tremor, insomnia
benzodiazepine withdrawal
psychomotor agitation, pupillary dilation, hypertension, euphoria, prolonged attentiveness/wakefulness, arrythmia, delusions, hallucinations, fever
amphetamine intoxication
depression, lethargy, stomach cramps, headache, hunger, hypersomnolence
amphetamine withdrawal
Treatment for:
euphoria, psychomotor agitation, pupillary dilation, hallucinations (tactile), paranoid ideations, angina
cocaine intoxication:
- benzodiazepines
Severe depression, suicidality, hypersomnolence, severe psychological craving for drug
cocaine withdrawal
restlessness, insomnia, increased diuresis, muscle twitching, arrythmia
caffeine intoxication
headache, lethargy, depression, weight gain
caffeine withdrawal
restlessness, insomnia, anxiety, arrythmia
nicotine intoxication
Treatment for:
irritability, headache, anxiety, weight gain, craving
nicotine withdrawal
- buproprion
- varenicline
belligerence, impulsiveness, fever, vertical and horizontal nystagmus, ataxia, homicidality, psychosis, delirium, tachycardia
PCP (phenylcyclidine) intoxication
Depression, anxiety, restlessness, anergia, disturbed thought/sleep
PCP (phenylcyclidine) withdrawal
Anxiety or depression, visual hallucinations, flashbacks, pupillary dilation, delusions
LSD intoxication
euphoria, anxiety, paranoid delusions, perception of slowed time, impaired judgment, social withdrawal, increased appetite, dry mouth, hallucinations
marijuana intoxication
irritability, depression, insomnia, nausea, anorexia peaking in 48 hours, lasting 5-7 days
marijuana withdrawal
What is suboxone? When is it used?
Naloxone + buprenorphine (partial opioid agonist):
- long acting
- fewer withdrawal Sx than methadone
- lower abuse potential (oral)
confusion
ophthalmoplegia
ataxia
Wernicke's encephalitis (thiamine deficiency)
memory loss
confabulation
personality change
Korsakoff's pyschosis (thiamine deficiency)
In what order to symptoms appear during DTs?
When do Sx peak?
autonomic hyperactivity --> psychotic Sx --> confusion

Peaks 2-5 days after last drink
periventricular hemorrhage
necrosis of mamillary bodies
thiamine deficiency (Wernicke-Korsakoff)
Haloperidol + "azines"
(Chlorpromazine, trifluoperazine, fluphenazine, thioridazine)

How do they work?
typical antipsychotics
(neuroleptics)

block D2 receptors
haloperidol
trifluoroperazine
fluphenazine
high potency antipsychotics --> neurologic side effects
chlorpromazine
thioridazine
low potency antipsychotics -->
non-neurologic side effects
chlorpromazine: corneal deposits
thioridazine: reTinal deposits
Treatment for:
rigidity, myoglobinuria, autonomic instability, hyperpyrexia (>106 F)
neuroleptic malignant syndrome
- dantrolene
- bromocriptine
In what order do extrapyramidal side effects arise from typical antipsychotics?
4 hours - acute dystonia
4 days - akinesia (Parkinsonism)
4 weeks - akathisia
4 months - tardive dyskinesia
olanzapine
clozapine
risperidone
aripiprazole
ziprasidone

How do they work?
atypical antipsychotics

Block 5-HT, alpha, H1, and D2 receptors
hypothyroidism
polyruria
heart block
sedation
edema
teratogenic
Lithium side effects
buspirone

How does it work?
5-HT 1A receptor agonist
Imipramine
Amitriptyline
Despiramine
Nortryptiline
Cloipramine
Doxepin
Amoxapine

How do they work?
tricyclic antidepressants

block NE and 5-HT reuptake
fluoxetine
paroxetine
citalopram
sertraline

How do they work?
SSRIs

Inhibit serotonin reuptake
Treatment for:
hyperthermia, muscle rigidity, CV collapse, flushing, diarrhea, seizures
serotonin syndrome
- cyproheptadine (5-HT antagonist)
venlafaxine
duloxetine

How do they work?
SNRIs

Inhibit serotonin and NE reuptake
phenelzine
tranylcypromine
isocarboxazid
selegiline

How do they work
MAOIs

Increased levels of amine NTs
hypertensive crisis
MAOI + B block or high tyramine food
priapism
trazodone
treatment for depression with insomnia
Mirtazapine