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17 Cards in this Set

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schizophrenia: age of onset?

men: 18-25 y/o




women: 25-35 y/o

mechanism of "atypical" antipsychotics?

serotonin & dopamine antagonists

major ADR of clozapine?

agranulocytosis

mechanism of "typical" antipsychotics?

dopamine antagonists

1st or 2nd gen antipsychotics: which is better for decreasing delusions in schizophrenia?

1st gen (good for positive S/Sx)




(e.g. haldol, chlorpromazine, thioridazine, loxapine, fluphenazine)

1st or 2nd gen antipsychotics: which is better for decreasing blunted affect/withdrawal in schizophrenia?

2nd gen (good for negative S/Sx)




(e.g. risperidone, paliperidone, asenapine, olanzipine, aripiprazole, ziprasidone, quetiapine)

how long must a pt be on an antipsychotic before you can conclude unresponsive?

4 - 6 weeks

Rx for schizophrenia resistant to first-line antipsychotic?

try combo antipsychotic + another drug




(e.g. carbamazepine, valproate, lithium, benzos)

side effects more likely to be seen w/ typical neuroleptics?

extrapyramidal Sx,


parkinsonian-like Sx,


neuroleptic malignant syndrome,


tardive dyskinesia

pt meets criteria for both a depressive/manic/mixed episode & schizophrenia - Dx?

schizoaffective disorder


(mix of psychotic & mood Sx)

how is schizoaffective different from mood disorder w/ psychotic features?

in schizoaffective, pt will have periods of delusions/hallucinations WITHOUT mood S/Sx




(criteria = x2 weeks)

which has a better prognosis, schizophrenia or schizoaffective disorder?

schizoaffective disorder

Tx schizoaffective disorder

2nd gen antipsychotic


(e.g. paliperidone)




+/- mood stabilizer (lithium, valproate)


or antidepressant

pt has nonbizarre delusions x 1+ month. Dx?

delusional disorder




(e.g. erotomanic, jealousy, persecutory)

Dx brief psychotic disorder?

S/Sx for at least 1 day but <1 mo


& pt returns to premorbid level of functioning




commonly after a catastrophic event

Dx schizophreniform disorder?

schizophrenic S/Sx for only 1-6 months

Dx of schizophrenia-related disorders over time?

<1 mo: brief psychotic disorder




1 mo - 6 mo: schizophreniform




>6 mo: schizophrenia