Psych Drugs

Front 1

First Generation Antipsychotics (typical):

MOA?

Major SE?

Back 1

MOA: block central DA rec

SE: EPS (Parkinsonian syndrome, acute dystonias, akathisia), Tardive Dyskinesias, Sedation, NMS, Anticholinergic Sx, CV effects(alpha-adrenergic blockade, cardiac rhythm disturbances), Endocrine effects( decreased DA leads to increased prolactin), Weight Gain

Front 2

Second Generation Antipsychotics (atypical):

MOA?

Major SE?

Back 2

MOA: serotonin-dopamine antagonist

SE: less likely to produce EPS, tardive dyskinesia, and NMS, but many have SE of their own that limit their use
**new concern that atypicals can increase risk of DMII (esp olanzapine and clozapine

Front 3

chlorpromazine:

Class?
t 1/2?
Potency?

Back 3

First Generation Antipsychotic: (Thorazine)
t 1/2: 24hrs
Potency: Low
**Sedation and orthostatic hypotension are very common

Front 4

haloperidol:

Class?
t 1/2?
Potency?

Back 4

First Generation Antipsychotic: (Haldol)
t 1/2: 24hrs
Potency: High
**EPS very common; available in IM Depot

Front 5

thoridazine:

Class?
t 1/2?
Potency?

Back 5

First Generation Antipsychotic:
t 1/2: 24hrs
Potency: Low
**Higher incidence of cardiac disturbances,retinitis pigmentosa

Front 6

mesoridazone:

Class?
t 1/2?
Potency?

Back 6

First Generation Antipsychotic:
t 1/2: 30hrs
Potency: Low
**Cardiac arrhythmias (torsades de pointes)

Front 7

fluphenazine:

Class?
t 1/2?
Potency?

Back 7

First Generation Antipsychotic:
t 1/2: 18hrs
Potency: High
**Available in a long-acting intramuscular depot

Front 8

molindone and loxapine are medium potency __________

Back 8

First Generation Antipsychotics

Front 9

trifluoperazine, thiothixene, perphenazine, and pimozide are high potency ___________

Back 9

First Generation Antipsychotics

Front 10

clozapine :

class?
t 1/2?
SE?

Back 10

Atypical Antipsychotic:
t 1/2: 5-15hrs
SE: AGRANULOCYTOSIS, anticholinergic Sx, weight gain, sedation, NMS
**CBC req weekly for 1st 6 mo and biweekly thereafter

Front 11

risperidone:

class?
t 1/2?
SE?

Back 11

Atypical Antipsychotic: (Risperdal)
t1/2: 3 in fast metabloizers, 120 in poor metabolizers
SE: Extrapyrimidal W/D syndrome in higher doses, postural hypotension, increased prolactin, weight gain, sedation, decreased concentration
**present in breast milk

Front 12

olanzapine:

class?
t 1/2?
SE?

Back 12

Atypical Antipsychotic: (Zyprexa)
t 1/2: 31hrs
SE: increased prolactin, orthostatic hypotension, anticholinergic SE, weight gain, somnolence
**alanine transferase levels as drug affects the liver

Front 13

quetiapine:

class?
t 1/2?
SE?

Back 13

Atypical Antipsychotic: (Seroquel)
t 1/2: 7hrs
SE: orthostatic hypotension, somnolence, transient increase in weight
**slit lamp exam at baseline and every 6mo for those at risk of developing cataracts

Front 14

ziprasidone:

class?
t 1/2?
SE?

Back 14

Atypical Antipsychotic: (Geodon, Zeldox)
t 1/2: 7hrs
SE: dose-related QT interval prolongation, postural hypotension, sedation
**present in breast milk, baseline K+ and Mg measurements

Front 15

ariprazole:

class?
t 1/2?
SE?

Back 15

Atypical Antipsychotic: (Abilify)
t 1/2: 75hrs
SE: HA, nausea, anxiety,insomnia, somnolence
**nonsedating, no increased risk of weight gain or diabetes

Front 16

In what way is aripiprazole different from other atypical antipsychotics?

Back 16

it is a partial agonist at DA and serotonin-1A receptors and antagonistic at postsynaptic serotonin-2A receptors allowing for less side effects