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46 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What areas of psychiatry can antipsychotics be used for?
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Psychosis and Mania
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Haloperidol
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Antipsychotic
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Trifluoperazine
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Antipsychotic
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Chlorpromazine
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Antipsychotic (sedating)
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Cheap (off label)
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Droperidol
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Antipsychotic (sedating), used only in ED for IM sedation
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Zuclopenthixol acuphase
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Antipsychotic depot, medium acting, for sedating very agitated patients
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What's the serious possible side effect of old antipsychotic depots?
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Tardive dyskinesia
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Clozapine
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Antipsychotic, old drug but atypical profile, used for treatment resistance. Works for 2/3
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Serious side effects of clozapine?
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Cardiac
-Myocarditis -Cardiomyopathy Agranulocytosis |
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Nuisance side effects of clozapine?
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-Weight gain
-Metabolic syndrome -Diabetes -Sedation -Hypersalivation (common) -Urinary incontinence (rare) |
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Respiradone (Type + SEs)
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Novel antipsychotic
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Hyperprolactinaemia +++
Extrapyramidal Weight gain Metabolic |
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Olanzapine (Type + SEs)
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Novel antipsychotic
-Metabolic +++ -Weight gain +++ -Sedation ++ |
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Quetiapine (Type + SEs)
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Novel antipsychotic
-Sedation ++ Weight gain + Metabolic + |
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Dothiapin (Type + SEs)
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TCA
-Anticholinergic SEs (OD risk) -Sedating |
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Doxepin (Type + SEs)
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TCA
-Anticholinergic SEs (OD risk) -Sedating |
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Amitryptiline (Type + SEs)
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TCA
-Anticholinergic SEs (OD risk) -Sedating |
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What's the problem with MAOIs?
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Food interactions with tyramine containing foods -> hypertensive crisis
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Sertraline
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SSRI - Zoloft
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Zoloft
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SSRI - Sertraline
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Fluoxetine
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SSRI - Prozac
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Prozac
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SSRI - Fluoxetine
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Citalopram
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SSRI - Cipramil
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Cipramil
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SSRI - Citalopram
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Escitalopram
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SSRI - Lexapro
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Lexapro
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SSRI - Excitalopram
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Fluvoxamine
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SSRI - Luvox
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Luvox
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SSRI - Fluvoxamine
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Paroxotine
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SSRI - Aropax
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Aropax
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SSRI - Paroxotine
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Side effects of SSRIs
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Agitation
Sedation (luvox) Nausea Anorexia Headache Sexual Discontinuation syndrome (fluoxetine not so bad) |
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Venlafaxine
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SNRI (efexor)
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Efexor
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SNRI (venlafaxine)
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Pristiq
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SNRI (desvenlafaxine)
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Desvenlafaxine
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SNRI (pristiq)
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Duloxetine
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SNRI (cymbalta)
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Cymbalta
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SNRI (duloxetine)
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Side effects of SNRIs
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Same as SSRIs + Hypertension
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Mirtazapine (Type + SEs)
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NaSSA (Avanza)
-Sedation -Weight gain Good drugs but problematic side effects - not first line |
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Avanza
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NaSSA (Mirtazapine)
-Sedation -Weight gain Good drugs but problematic side effects - not first line |
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3 Important things RE starting/stopping antidepressants
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-Will have mild side effects for ~5 days, should dissapear in a week
-Start and stop on half dose for a week -Length of treatment ->1st episode - 6m+ -> 2nd episode - 2y+ -> 3rd+ episide - 5y-life |
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Lithium Carbonate
-What's it good and bad at? -Why monitor? -Side effects? -Toxicity signs+symptoms? |
Excellent at preventing relapses. Not a good antidepressant or antipsychotic.
Narrow therapeutic window, so monitor closely Side Effects -Metallic taste -Polyuria -Polydipsia -Fine tremor -Rare teratogenic effect Chronic Toxicity -Neurological signs Acute toxicity -Coarse tremor -Nausea and Vomiting -Comatose -Death -Need dialysis |
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Sodium valproate vs Lithium
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Valproate is teratogenic, and does not have as good evidence for it.
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Side Effects of Sodium Valproate
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Liver impairment
Neutropenia PCOS Sedation |
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Carbamezapine
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Mood stabiliser
Anticonvulsant |
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Lamotrigine
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Mood stabiliser
Anticonvulsant |
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Topiramate
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Mood stabiliser
Anticonvulsant |
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