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35 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Alcohol withdrawal
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Alcohol withdrawal - Benzo's
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Anorexia/bulimia
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anorexia - SSRIs
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Anxiety
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Anxiety - Benzo, Buspirone, SSRI
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ADHD
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ADHD - methyphenydate (ritalin), Amphetamine
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Atypical depression
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Atypical depression - SSRI's, MAOi
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Bipolar disorder
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Bipolar - "Mood stabilizers"
- Lithium - Valproic acid - Carbamazepine Atypical antypsychotics (risperidone) |
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Depression
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Depression - SSRIs, SNRIs, TCAs
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Depression with insomnia
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Depression/insomnia - Mirtazapine
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OCD
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OCD - SSRIs, Clomipramine
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Panic Disorder
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panic - SSRIs, TCAs, benzos
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PTSD
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PTSD - SSRI
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Schizophrenia
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Schizophrenia - antipsychotics
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Tourette's
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Tourrettes - antipsychotics (haloperidol)
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Social phobias
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Social phobias - SSRIs
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What are the typical antipyshcotics?
What are their effects? |
Typical antipsychotics: haloperidol + -azines
- haloperidol - |
Typical antipsychotics
Block dopamine D2 receptor (increases cAMP) |
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What are the atypical antipsychotics?
What are their effects? |
Atypical antipsychotics:
Risperidone Ziprasidone Olanzapine Quetiapine Clozapine Aripiprazole |
Atypical antipsychotics:
Block 5HT, alpha, dopamine and H1 receptors |
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Patient has been given a medication for recent hallucinations. Now he is feverish, rigid, has very low BP and is hyperreflexive.
1. What drug was he given initially? 2. What occurred later and what should he be given now? |
Schizophrenia --> given a typical antipsychotic that caused neuroleptic malignant syndrome. Now, give him either dantrolene or a dopamine agonist (bromocriptine).
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Which of the antipsychotic drugs can cause agrunolcytosis?
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Clozapine, an atypical antipsychotic can cause agranulocytosis.
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Which of the antipsychotics can cause deposition in the eyes?
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Typical antipsychotics:
Chlorpromazine - corneal deposits Thioridazine - retinal deposits |
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What side effects of the neuroleptics are mechanistic?
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Neuroleptics are typical antipsycohtics (haloperidol and -azines)
Muscarinic - dry mouth, constipation Alpha - hypotension Histamine - sedation |
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What are the side effects of lithium?
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Lithium (bipolar) - LMNOP
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Lithium side effects
Movement (tremor) Nephrogenic DI hypOthyroid Pregnancy problems (Ebstein anomaly) |
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How does buspirone work and what is it used for?
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Buspirone is a 5-HT 1A receptor agonist. It is used to treat general anxiety disorder and does not interact with alcohol or cause sedation, addiction or tolerance (as opposed to barbs or benzos).
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What are the tricyclic antidepressants?
What do they do? |
TCA's - imipramine, amitryptaline, desipramine, nortriptyline, clomipramine, doxepin, amoxapine
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TCAs block reuptake of NE and serotonin
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What drug is used to Tx bedwetting?
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Bedwetting - imipramine (TCA)
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What TCA is used to treat OCD?
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OCD - clomipramine (TCA)
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Which TCA is the least sedating?
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Of the TCA's, desipramine is the least sedating.
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Which TCA has less anticholinergic side effects? Why is this important in the treatment of elderly patients?
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TCAs can cause anticholinergic side effects (tachy, urinary retention) that are worse in amitriptyline and less in nortriptyline. In the elderly, this may cause confusion and hallucinations.
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How is TCA CV toxicity treated?
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TCA CV toxicity (cardiotoxicity) --> NaHCO3
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What are the three main toxicities of TCA's?
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TCA's - TriC - Cardiotoxicity, Convulsions, Coma
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What are the SSRI's? What are the SEx of these drugs?
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SSRIs:
- Fluoxetine - Paroxetine - Sertraline - Citalopram |
SSRIs SEx:
- Anorgasmia (sexual dysfunction) - Serotonin syndrome (+MAOi): hyperthermia, muscle rigidity, cv collapse, flushing, diarrhea, seizures |
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How is serotonin syndrome treated?
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Serotonin syndrome --> cyproheptadine - a 5-HT receptor antagonist
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What are the SNRIs? SEx?
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SNRIs:
- Venlafaxine - Duloxetine |
SNRI SEx:
- mainly HTN - Stimulant effects - Sedation - Nausea |
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What drug is indicated for diabetic peripheral neuropathy?
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DM neuropathy - duloxetine
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What are the MAOi's and which is MAO-B specific?
SEx? |
MAOi:
- Phenelzine - Tranylcypromine - Isocarboxazid - Selegiline *MAO-B specific |
MAOi SEx:
- Hypertensive crisis with tyramine ingestion (red wine, cheese) and B-agonists - CNS stimulation - Serotonin syndrome w/ SSRIs or meperidone |
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What are the atypical antidepressants?
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Atypical antidepressants:
Buproprion (smoking as well) Mirtazapine (a2 and 5HTr antagonist) Maprotiline (blocks NE reuptake) Trazodone (inh serotonin reuptake, used for insomnia) |
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