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11 Cards in this Set

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Four characteristic brain hallmarks in Alz
accumulation of amyloid plaques
presence of NF tangles
degeneration of cholinergic neurons
cortical atrophy
Cautions with AChE inhibitors
bradycardia, conduction blocks, ulcers, incontinence, asthmatics, cholinergic agents
HIDE acronym for causes of delirium
hypoxia
infection
drugs
electrolytes
Differences between delirium and dementia
Dementia: easy to awaken, slow development
Delirium: hard to awaken, fast development
5 A's of Alz decline
aggression
agitation
anxiety
apathy
appetite
Stage 1 sx
gets lost, personality changes, trouble finding words

2-4 years
Stage 2 sx
memory & functional problems, forget time & date, losing ability to dress & communicate

2-10 years
Stage 3 sx
incontinent, limited speech, wandering, stiff muscles, delusions, hallucinations, death

1-3 years
Testing for Alz
thyroid function, syphillis, B12, folate, head CT, ApoE genotyping
MOA of epistigmine
long acting SR release AChE inhibitor
Other possible tx for Alz
gingko, sage, lemon balm, vit E, estrogens, SSRIs, NSAIDs