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11 Cards in this Set
- Front
- Back
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Four characteristic brain hallmarks in Alz
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accumulation of amyloid plaques
presence of NF tangles degeneration of cholinergic neurons cortical atrophy |
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Cautions with AChE inhibitors
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bradycardia, conduction blocks, ulcers, incontinence, asthmatics, cholinergic agents
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HIDE acronym for causes of delirium
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hypoxia
infection drugs electrolytes |
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Differences between delirium and dementia
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Dementia: easy to awaken, slow development
Delirium: hard to awaken, fast development |
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5 A's of Alz decline
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aggression
agitation anxiety apathy appetite |
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Stage 1 sx
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gets lost, personality changes, trouble finding words
2-4 years |
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Stage 2 sx
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memory & functional problems, forget time & date, losing ability to dress & communicate
2-10 years |
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Stage 3 sx
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incontinent, limited speech, wandering, stiff muscles, delusions, hallucinations, death
1-3 years |
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Testing for Alz
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thyroid function, syphillis, B12, folate, head CT, ApoE genotyping
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MOA of epistigmine
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long acting SR release AChE inhibitor
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Other possible tx for Alz
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gingko, sage, lemon balm, vit E, estrogens, SSRIs, NSAIDs
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