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34 Cards in this Set

  • Front
  • Back

incidence

number of new cases/fixed time period

prevalence

number of cases/fixed time period

schizophrenia affects

men and women equally


major depressive disorder

leading cause of disability in US


nearly 2Xs as many women as men suffer



bipolar disorder affects

men and women equally

generalized anxiety DO

can begin across life cycle


highest between childhood and middle age



panic DO

typically begins in adolescence or early adulthood


about 1 in 3 people with this DO develop agoraphobia

obsessive-compulsive DO

first symptoms begin in childhood or adolescence

PTSD

can develop anytime

social phobia

typically begins in childhood or adolescence

agoraphobia

begins in young adulthood

specific phobia

begins in childhood

antisocial personality DO

more common in men

alzheimer's D

rare, inherited forms can strike in the 30s-40s

monoamines

dopamine


norepinephrine


serotonin


hestamine

dopamine receptors

D1, D2, D3, D4, D5

norepinephrine receptors

alpha1, alpha2, beta1, beta2



serotonin receptors

5-HT1, 5-HT2, 5-HT3, 5-HT4

histamine receptors

H1, H2

dopamine effects

  1. fine muscle movement
  2. integration of emotions and thoughts
  3. decision making
  4. stimulates hypothalamus to release hormones (sex, thyroid, adrenal)

norepinephrine effects


  1. level in brain affects mood
  2. attention and arousal
  3. stimulates "fight or flight" response to stress


serotonin effects

  1. sleep regulation, hunger, mood states and pain perception
  2. hormonal activity
  3. aggression and sexual behavior

histamine


  1. alertness
  2. inflammatory response
  3. stimulate gastric secretion

peptides (neuromodulators)


  1. substance P
  2. somatostatin (SRIF)
  3. neurotensin (NT)

glutamate receptors


  1. NMDA
  2. AMPA


acetylcholine receptors


  1. nicotinic
  2. muscarinic (M1, M2, M3)

substance P receptors

SP

somtostatin receptors

SRIF

neurotensin receptors

NT

gamma aminobutyric acid effects


  1. role in inhibition;reduces aggression, excitation and anxiety
  2. may play a role in pain perception
  3. has anticonvulsant and muscle-relaxing properties
  4. may impair cognition and psychomotor functioning

glutamate effects


  1. excitatory
  2. AMPA plays a role in learning and memory

acetylcholine effects


  1. role in learning, memory
  2. regulates mood: mania, sexual aggression
  3. affects sexual and aggressive behavior
  4. stimulates parasympathetic nervous sys

substance P effects

  1. centrally active SP antagonist has antidepressant and anti-anxiety effects in depression
  2. promotes and reinforces memory
  3. enhances sensitivity to pain receptors to activate

somatostatin effects

  1. endogenous antipsychotic-like properties