Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key


Play button


Play button




Click to flip

45 Cards in this Set

  • Front
  • Back
Incidence of schizophrenia?
Findings on autopsy of schizo?
decreased brain volume, decreased basal activity in prefrontal cortex, decreased GABAergic interneurons
Association between positive sx and area of brain?
Increased mesolimbic activity
Association between negative sx and area of brain?
Decreased mesocortical activity
What are reciprocal synpases?
Serotonin receptors expressed on dopaminergic neurons
Hallucinogens are partial agonists at what receptors?
Agents that induce psychosis?
psychostimulants (cocaine, amphet.)
dissociative anesthetics (katemin, PCP)
How do psychostimulants cause psychosis?
Increase synaptic monoamine concentrations
How do Dissociative Anesthetics cause psychosis?
NMDA antagonists
Effect of dopamine antagonism on mesolimbic tract?
Decreased positive sx
Effect of dopamine antagonism on mesocorticol tract?
Increased negative sx
Effect of dopamine antagonism on nigrostriatial tract?
EPS effects, parkinsonism
Effect of dopamine antagonism on tuberlofundibular tract?
Signal transduction of D1/D5 receptors?
Signal transduction of D2-4 receptors?
For which sx do atypicals have improved action?
negative sx
What are the aliphatic phenothiazines?
chlorpromazine, triflupromazine, promazine
What are the piperidine phenothiazines?
thioridazine, mesoridazine
What are the piperazine phenothiazines?
fluphenazine, trifluoperazine, pephenazine
What is the aliphatic thioxanthine?
What is the piperazine thioxanthine?
What are the butyrophenones?
haloperidol, droperidol, pimozide
Two classes of atypicals?
benzepines, others
What are the benzepines?
loxapine, clozapine, quetiapine, olanzapine
What are the other atypicals?
molindone, risperidone, ziprasidone, aripiprazole
What is the low potency phenthiozine?
What is the high potency phenthiozine?
What is the low potency thioxanthine?
What is the high potency thioxanthine?
What is the binding affinity of typical agents?
High D2
Low 5HT2-a
What is the binding affinity of atypical agents?
Mod-High D2
High 5HT2-a
What is the binding affinity of clozapine-like agents (and what does that include)?
Low D2
High 5HT2-a

Clozapine & quetiapine
What is the receptor action of aripiprazole?
mixed dopaminergic agonism & antagonism
Low potency agents have what kind of side effects?
low EPS, high sedation, orthostasis, and anticholinergic
High potency agents have what kind of side effects?
high EPS, low sedation, orthostasis, and anticholinergic
What receptor action may be permissive for EPS effects?
D1 antagonism
What is dystonia?
facial grimacing, twisting movements, torticollis
Sx of Parkinsonism?
tremor, rigidity, akinesia/bradykinesia, postural instability
Sx of Neuroleptic Malignant Syndrome?
severe Parkinsonism, hyperthermia, autonomic dysfunction
Tx for Neuroleptic Malignant Syndrome?
D/C agent, bromocriptine, dantrolene
Why do antipsychotics cause seizures, and which drugs have greatest incidence?
GABA depletion

chlorpromazine, clozapine
CV side effects of antipsychotics?
orthostasis, reflex tachycardia, QT prolongation, arryhthmias
Endocrine side effects of antipsychotics?
hyperprolactinemia, weight gain, diabetes
Genitourinary side effects via alpha-1 receptor?
muscarinic receptor?
sexual dysfunction

urinary retention
Hematological side effects?
agranulocytosis, eosinophilia, leukocytosis