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54 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Question
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Answer
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Hint
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Name 4 GSK Values
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Transparency, Respect, Integrity, Patient Focused
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TRIP
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Definition of Psoriasis?
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a chronic, noncontagious, inflammatory disease of the skin.
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p.5
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What is the most common type of psoriasis?
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Plaque
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p.5
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Approx what % of patients diagnosed with Psoriasis have plaque psoriasis?
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80%
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p.11
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How many Americans have psoriasis?
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7.5 million, approx 2.2% of population
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p.23
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Psoriasis is the most prevalent what in the US?
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auto-immune disease
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p.6
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What are physical characteristics of plaque psoriasis?
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Appears as raised, red lesions, which are typically characterized by seilvery white scales over reddened, itchy, and painful skin.
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p.5
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Where on the body is plaque psoriasis most commonly found?
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scalp, knees, elbows, and torso.
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p.5
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Psoriasis severity can be measured by BSA. The palm of your hand equals about what percent of skin surface?
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1%
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p.6
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The NPF classifies psoriasis into 3 categories, which are called what? And definition of each?
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Mild= Less than 3% of the body is affected; Moderate=Between 3%-10% of the body is affected; Severe= More than 10 % of the body is affected.
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p.6
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The cause of psoriasis is multifactoral, what are the 2 components?
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Genetic and Environmental
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p.7
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What are environmental factors which may trigger an episode of psoriasis?
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Stress, Physical trauma, enfection, medications.
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p.7
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If both parents are affected with psoriasis, what is a child's risk of being psoriatic?
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50%
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p.7
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If one parent is affected with psoriasis, what is a child's risk?
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10%
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p.7
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Psoriasis is often referred to as the what kind of disease?
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T-CELL Mediated disease
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p.9
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Describe T-CELL Mediated disease
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The eruption of psoriatic skin lesions coincides with T cells ending up in the skin and becoming activated, leading to an inappropriate immune response.
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p.9
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What is normal skin turnover vs psoriatic skin turnover?
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Normal=28-45 days; PsO=-3-4 days
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Plaque psoriasis is also known as what?
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Psoriasis Vulgaris
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p.11
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T cell
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cell critical to the immune system that include Helper & Cytoxic
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p.8
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B cell
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cells that can be differentiated into Plasma cells and Memeory cells
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p.8
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Antigens
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Any substance that can provoke an immune response
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p.8
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AntiBodies
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Souluble proteins secreted by active B cells (or Plasma cells) in response o an antigen
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p.9
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PhagoCytes
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cells capable of engulfing and digesting particles or cells harmful to the body
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p.9
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Erythrodermic
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Inflammatory form of Pso that typically covers most f the body
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p.12
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Guttate
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Pso characterized by small, red spots on the skiin localized to trunk or limbs
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p.12
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Pustular
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form of pso characterized by blisters or non-infectious pus consisting of white blood cells surrounded by skin
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p.13
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Plaque
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Most common type of pso
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Scalp
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appears in at least half of those who have disease
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p.14
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Inverse
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form of pso characterized by vert red lesions in the body folds
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armpits, groin, under breast
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What are 4 treatment strategies for pso?
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monotherapy, combination, rotational, sequential
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p.17
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Monotherapy
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use of one therapeutic agent
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p.17
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Combination therapy
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use of two or more agents at one time
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p.17
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Rotational therapy
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alternate therapy after specific durations
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p.17
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Sequential therapy
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3 phases: clear, transition, maintain
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p.17
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What is the mainstay of treatment for most patients with pso?
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topical monotherapy
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p.17
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Name Topical treatments for pso
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moisturizers, steroids, salicylic acid, coal tar, anthralin, retinoids, vitD3 analogs
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p.18
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Moisturizers
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used daily to keep skini moistened
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p.17
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Corticosteroids
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Most commonly prescribed agen for treating mild-mod pso; 7 classes
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p.18
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Salicylic Acid
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keralytic, commonly 1st-line treatment for scalp pso in form of shampoo
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p.18
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Coal Tar
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can help slow growth of skin cells, reduce inflammation, itching, and scaling.
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p.18
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Anthralin
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yellowish cream treats mild-moderate pso
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p.18
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Retinoids
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analog of vitamin A; often combined with steroids to reduce irritation and increase steroid efficacy
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p.18
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Vitamin D3 Analogs
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bind to vitamin D receptor and may inhibit growth of skin cells
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p.18
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Phototherapy
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mechanism of action appears to involve selective depletion of T cells
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p.19
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What are 2 categories of systemic therapies for psoriasis?
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traditional systemics and biologics
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p.19
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Name all systemic therapies for PsO treatment
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acitretin, methotrexate,cyclosporin, biologics
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p.20
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What are 2 classes of biologics for treatment of psoriasis?
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T-cell inhibitors + Cytokine inhibitors
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p.21
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Example of acitretin
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soriatane
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p.20
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What are forms of methotrexate?
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oral, IM, IV
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p.20
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Methotrexate is an example of this type of therapy
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Systemic
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p.22
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This type of therapy targets specific steps in the immune pathway critical to the pathogenesis of psoriasis?
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Biologic
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p.22
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Vitamin D3 Analogs are an example of this type of therapy
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Topical
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p.22
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T or F: No cure currently exists for psoriasis?
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TRUE
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here are a number of treatments that can help manage pso
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