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20 Cards in this Set
- Front
- Back
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Define psoriasis. |
A chronic, non-infectious, inflammatory disorder of the skin. |
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What are the different classifications of Psoriasis? |
- Psoriasis Vulgaris: acute guttate, chronic stable plaque, palmoplantar, inverse - Psoriasis erythroderma - Pustular psoriasis: eg palmoplanar putulosis |
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What ages are mostly affected by psoriasis vulgaris? |
Ages: 2 peaks - 22 and 55 |
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Is psoriasis more common in a particular sex? |
No. Equal incidence in both. |
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What are some known trigger factors for psoriasis? |
Trauma Stress Drugs Alcohol |
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Which drugs have been shown to precipitate a psoriasiform drug reaction? |
Systemic corticosteroids Oral lithium Anitmalarias Interferon B- adrenergic blockers |
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Briefly discuss the role of keratinocytes in the pathogenesis of psoriasis. |
There is an alteration in the cell kinetics of the keratinocytes resulting in a shortening of the cell cycle which then leads to an overproduction of epidermal cells. |
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What are the two major clinical manifestations of psoriasis vulgaris? |
1. Eruptive, inflammatory type. 2. Chronic stable (plaque) psoriasis |
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How does the eruptive, inflammatory clinical type of psoriasis vulgaris present? |
Multiple small, well defined reddish or salmon pink papules with a loosely adherent silvery-white lamellar scale. |
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How does the chronic stable clinical type of psoriasis vulgaris present? |
Sharply marginated dull red plaques with loosely adherent lamellar silvery-white scales. |
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What is the auspitz sign of psoriasis? |
When the scales are removed and there is bleeding from pin points seen. |
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What is the typical distribution of acute guttate psoriasis? |
Disseminated, generalized, mainly on the trunk. |
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What is the typical distribution of the chronic stable type of psoriasis? |
Can be a single lesion or on the elbows, knees, sacral gluteal region, scalp and palms/soles. It can be generalized. |
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How does psoriasis on the hands and soles typically present? |
Massive silvery white or yellowish hyperkeratosis which is not easily removed. |
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What are the nail changes associated with psoriasis? |
Thimble pitting Onycholysis Subungal hyperkeratosis "Oil drop" discoloration- (pathognomonic) Splinter hemorrhages |
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What infection typically precedes acute guttate psoriasis? |
Streptococcal throat infection |
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What is the typical presentation of generalized acute pustular psoriasis? |
Burning, fiery-red erythema topped by pinpoint sterile yellow pustules in clusters spreading within hours over entire body. Coalescing lesions form lakes of pus that are easily wiped up. |
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What is the presentation of psoriatic arthritis? |
Asymmetric peripheral joint involvement of upper extremities and especially DIP joints. Also dactylitis with characteristics sausage fingers. |
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What is the presentation of psoriatic arthritis? |
Asymmetric peripheral joint involvement of upper extremities and especially DIP joints. Also dactylitis with characteristics sausage fingers. Can also affect the vertebral column and sacroilitiac joints. |
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Psoriasis of the nails is commonly associated with what disease process? |
Psoriasis arthritis |
