Psl 534 Old Material 2

Front 1

Cells can undergo apoptosis (programmed cell death) in response to "stress." Which of the
following most likely mediates the specific branch of the mitogen-activated protein kinase
(MAP kinase) pathway that delivers the "stress" signal?

Back 1

Jun N-terminal kinase (JNK)

Front 2

Exogenous glucocorticoids are useful in treating a variety of diseases because they exert
"anti-inflammatory" effects when given in supra-physiological doses. Glucocorticoids exert
this anti-inflammatory effect by directly inhibiting which of the following enzymes?

Back 2

phospholipase A2

Front 3

Which of the following physiological compounds does lower blood pressure?

Back 3

A. atrionatriuretic factor (ANF)
B. nitric oxide (NO)
C. prostacyclin I2 (PGI2)

Front 4

Hemoglobin is an important carrier of gases in the blood. The gases that bind to hemoglobin
include:

Back 4

A. O2
B. CO2
C. NO

Front 5

Some patients treated chronically with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
experience serious gastrointestinal (GI) side effects, including bleeding, ulceration, and
perforation. Among 5285 patients who took the drug CelebrexTM in doses of 200 mg/day (or
higher) over a period of 1-6 months, only 2 patients (0.04%) experienced serious upper GI
bleeding. This is a significantly lower frequency of GI bleeding than was observed with
patients who took ibuprofen. Based on your knowledge of the expression and activities of
the PGH synthase (COX) isozymes, the best biochemical rationalization for the lower
frequency of bleeding in the patients who took Celebrex is that Celebrex binds:

Back 5

COX-2 better than COX-1

Front 6

Which of the following properties is shared by the v-erb B2 oncoprotein (gp65v-erb B2) and
the receptor for epidermal growth factor (EGFR)?

Back 6

phosphorylating tyrosine residues of target proteins

Front 7

Which of the following properties is shared by ERK (extracellular signal-regulated kinase),
p38 MAPK (p38 mitogen-activated protein kinase), and JNK (Jun N-terminal kinase)?

Back 7

phosphorylating serine/threonine residues of transcription factors

Front 8

In the list below, a drug is paired with an enzyme that it affects. Which of these pairs would
affect most generally total eicosanoid production?

Back 8

cortisone --- phospholipase A2

Front 9

Leukotriene B4 :

Back 9

contracts non-vascular smooth muscle

Front 10

Which one of the following has, as one of its major effects, the ability to inhibit platelet
aggregation?

Back 10

prostacyclin I2

Front 11

Starting with the amino acid arginine, endothelial cells can produce a hormone that:

Back 11

acts as a vasodilator

Front 12

Which of the following properties is shared by MAPKKK, MAPKK, and MAPK?

Back 12

phosphorylating serine/threonine residues of target proteins

Front 13

Proteins with SH2 domains directly bind to:

Back 13

phosphorylated tyrosine (PO4 -Tyr)

Front 14

A 25-year-old woman with a history of asthma is brought to the emergency room because of
severe bronchospasm (contraction of bronchial smooth muscle, which constricts the small
airways and makes breathing difficult). Given her history, you asked her if she took aspirin
before this latest episode of bronchospasm. The possible link between aspirin and
bronchospasm is based on the fact that aspirin:

Back 14

inhibits the cycloxygenase pathway but leaves the lipoxygenase pathway unchecked

Front 15

Which of the following anti-inflammatory drugs might be most useful in treating the
bronchospasm associated with asthma?

Back 15

cortisone

Front 16

Which of the following statements regarding atrial natriuretic factor (ANF) is true?

Back 16

ANF decreases the production of aldosterone by the adrenal cortex.

Front 17

A new generation of non-steroidal anti-inflammatory drugs has been developed for relief of
inflammation and pain due to arthritis (inflammation of joints), without inducing
gastrointestinal ulcer. The basis for this specificity is that the drugs selectively inhibit:

Back 17

PGH synthase-2 (Cox-2)

Front 18

Nitroglycerin, a drug frequently used by patients with angina pectoris (heart pain caused by
myocardial ischemia), is converted in the body to a compound which:

Back 18

acts as a vasodilator

Front 19

The prostacyclin PGI2, produced by endothelial cells, inhibits platelet aggregation and
prevents the adhesion of platelets onto the walls of healthy blood vessels. The thromboxane
TxA2, produced by platelets, promotes platelet aggregation. What is the effect of daily
ingestion of a single low dose of aspirin?

Back 19

shift the PGI2/TxA2 ratio in favor of PGI2

Front 20

The product of the v-src oncogene is a:

Back 20

protein tyrosine kinase