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56 Cards in this Set
- Front
- Back
Pseudomonas: Describe the basics of this bug?
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1. aerobic
2. motile 3. can use lots of carbon sources |
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Pseudomonas: What causes the blue-green pigment?
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pyocyanin
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Pseudomonas: Who gets this infection?
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burn victims, immunocomp., drug users
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Pseudomonas: What are the clinical syndromes?
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PSEUDOmonas
Pneumonia, Sepsis, External Otitis, UTI, Drug/Diabetic Osteomyelitis |
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Pseudomonas: Found in what environments?
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moist
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Pseudomonas: Can it be normal gut flora?
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yes
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Pseudomonas: What virulence factor causes attachment to host cell epithelium?
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adhesin
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Pseudomonas: What virulence factor causes the formation of a mucoid layer?
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alginate
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Pseudomonas: What virulence factors cause inhibition of host protein production
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1. Exotoxin A
2. Exoenzyme S |
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Pseudomonas: What virulence activity causes damage to lung and blood vessels
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Elastolytic activity
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Pseudomonas: Describe Exotoxin A.
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- ADP- ribosylation (A-B exotoxin)
- attaches to EF-2 - turns off translation |
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Pseudomonas: What other bug has a toxin similar to exotoxin A?
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C. diptheria
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Pseudomonas: bug preys on people with what genetic lung pathology
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CF
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Pseudomonas: How does bug aggravate CF?
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- Increased secretion of muscin
- frustrated macros release cytokines |
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Pseudomonas: Tx?
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aminoglycosides and B-lactam (tick, pipe, car)
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Bordella Pertussis: Causes what major symptom?
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whooping cough
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Bordella Pertussis: What kind of media required?
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Bordet-Gengou (potato) agar
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Bordella Pertussis: aerobic or anaerobic?
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aerobic
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Bordella Pertussis: What virulence factor ADP-ribosylates guanine nucleotide binding protein?
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pertussis toxin
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Bordella Pertussis: What are the 2 main results of pertussis toxin?
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1. lymphocytosis
2. hypoglycemia |
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Bordella Pertussis: What virulence factor mediates attachment to the resp. epithelium?
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pertussis toxin
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Bordella Pertussis: What is the function of the adenylate cyclase toxin?
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inhibits Gi, causes local edema
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Bordella Pertussis: What are the 4 main virulence factors?
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1. pertussis toxin
2. adenylate cyclase toxin 3. tracheal cytotoxin 4. dermonecrotic toxin |
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Bordella Pertussis: what does the tracheal cytotoxin do?
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causes cilistatis
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Bordella Pertussis: what does the dermonecrotic cytotoxin do?
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- vascular smc contraction
- ischemic necrosis |
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Bordella Pertussis: What other factor causes attachment to epithelial cells and erythrocyte agglutination?
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filamentous hemaglutinin
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Bordella Pertussis: Is there a vaccine?
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No
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Bordella Pertussis: Who is mainly affected?
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historically children under 5, but lately people over 20
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Bordella Pertussis: What is the mechanism of transmission?
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aerosol
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Francisella tularensis: Causes what disease?
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Tularemia
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Tularemia: Are these bugs small?
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yes
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Tularemia: What is another name for the fever they cause?
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glandular, tick, rabbit or deerfly fever
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Tularemia: What are the animal reservoirs?
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arthropods, rabbits, etc
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Tularemia: How many bugs needed for infection?
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inhalation = 50
ingestion - 100 million |
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Tularemia: what occupation is at risk?
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hunters
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Tularemia: What are the 2 main presentations?
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1. Glandular
2. Typhoidal |
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Tularemia: How do you get glandular tularemia?
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direct contact or arthropod bite
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Tularemia: What are the symptoms of glandular tularemia?
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- lymph involvement
- no ulcers |
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Tularemia: What are the symptoms of ulceroglandular tularemia
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- necrotic ulcer
- regional lymphadenopathy |
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Tularemia: What are the symptoms of oculoglandular tularemia
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- conjunctivitis
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Tularemia: How do you get typhoidal tularemia?
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eating contaminated meat or aerosol exposure
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Tularemia: What is the major symptom of typhoidal tularemia?
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long term fever similar to S. typhi
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Tularemia: What cell does the bug live in?
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macrophage
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Tularemia: What is the mechanism of necrotic lesions?
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inflammatory response causing granuloma formation
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Tularemia: What causes the typhoid fever?
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endotoxin
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Tularemia: Why is this bug considered a potential bioweapon?
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- low number of bugs necessary for inhalation infection
- aerosol |
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Tularemia: Tx?
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streptomycin, since bugs secrete beta-lactamase
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Brucella: What are the 4 important species?
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B. abortus (cattle)
B. melitensis (goats) B. suis (pigs) B. canis (dogs) |
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Brucella: What is the main feature of brucellosis?
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undulant fever
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Brucella: What are some other terms describing undulant fever?
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- Malta fever
- Meditteranian fever |
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Brucella: What are the main animal hosts?
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cattle, sheep, goats
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Brucella: Who gets this bug?
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- people who work with animals
- eat unpastuerized cheese |
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Brucella: How are the animals affects by this bug?
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- usually appear healthy
- may have abortions |
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Brucella: Where does this bug replicate?
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macrophage
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Brucella: What organs does this bug infect?
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liver, spleen, BM
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Brucella: how is this bug released periodically from a point in the body?
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From a granuloma
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