Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
24 Cards in this Set
- Front
- Back
|
what percent of p. falciparum progress to severe malaria
|
10%
|
|
|
what is the best predictor of death
|
respiratory distress
due to metabolic acidosis |
|
|
what are the many complications of p. falciparum
|
cerebral malaria
severe anemia resp distress hyperpyrexia hypoglycemia Gi/liver symptoms renal failure circulatory collapse |
|
|
which part of the blood do p.o. and p.v. usually infect
|
reticulocyes
|
|
|
which part of the blood do p.m. infect
|
senescent RBC
|
|
|
which part of the blood does p.f. infect
|
all erythrocytes are invaded
|
|
|
what does p.f. avoid in the body
|
spleen
|
|
|
what does p.f. express on the surface of infected erythrocyes
|
knobs
knobs mediate cytoadherence to endothelial cells |
|
|
what symptoms do you see with cerebral malaria
|
encephalopathy
loss of consciousness severe headache drowsiness confusion coma convulsions |
|
|
what is cerebral malaria correlated with that causes it?
|
sequestration of infected erythrocytes in micro vasculature of brain
|
|
|
what two things contribute to the complications of p. f.
|
high parasitemias
sequestrations |
|
|
cytoadherence mediated by?
|
knobs and Pfemp1 (var gene)
what??? |
|
|
how do you diagnose malaria
|
symptoms
travel history splenomegaly and anemia as dz progresses blood smear antigen testing (dipstick) |
|
|
what should you do if blood smears are negative
|
repeart every 12 hours for 48 hours
|
|
|
is there a rapid test for malaria?
|
yes
rapid antigen detection (dipstick) |
|
|
which stage does p.v. and p.o have that others dont?
|
hypnozoite stage
|
|
|
which spp has has sequestration
|
p.f.
|
|
|
why might people not want to use antigen testing dipstick
|
cost
|
|
|
which drug should be used first if no resistance
|
chloroquine
|
|
|
what drug should be used for p.v./p.o. with no resistance
|
CQ + primaquine
|
|
|
what drug should be used if there is chloroquine resistance or it is not known
|
fansidar
mefloquine quinine artemisinin derivatives |
|
|
what drugs should be used in severe malaria
|
IV quinine or quinidine
IV artemisinin derivatives |
|
|
what is one way to prevent relapses in malaria
|
treat hyponozoites stage in p.v/p.o.
|
|
|
what drugs should be used as presumptive or standby treatments
|
fansidar
mefloquine quinine |
