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24 Cards in this Set

  • Front
  • Back
Name two major Alpha-1 Globulins.
A1-Antitrypsin
A-lipoprotein
Name three major Alpha-2 Globulins.
A2-macroglobulin
Haptoglobin
Ceruloplasmin
Name two major Beta-1 Globulins.
Transferrin
B-lipoprotein
Name two major Beta-2 Globulins.
Fibrinogen
C3 (complement)
What is the major class of Gamma globulins?
Immunoglobulins
Name two major functions of albumin.
Transport (drugs, fatty acids, bilirubin)
Maintaining oncotic pressure
Name one cause of edema.
Hypoalbuminemia
What is analbuminemia? How is it compensated?
Inherited hypoalbuminemia
Increased Alpha-2s
What binds retinol and thyroid hormone/
Prealbumin
B2-microglobulin, a subunit of HLA (Human Leukocyte Ag), is used to detect what/
Renal failure
Name two proteins used to detect renal failure/nephrotic syndrome.
B2-Micro
A2-macro
Alpha-FP is used to detect what three sydromes?
Spina bifida
Down's syndrome
Liver cancer
What is the role of haptoglobin?
Binding AB dimers of Hb, and transporting them to spleen for degradtion.
Decreased haptoglobin is associated with what?
What about increase?
Anemia
Hemolysis
Can haptoglobin bind myoglobin?
No
If tehre is blood in teh urine, but haptoglobin count is normal, where is the blood from?
Mb/muscle tissue
What is the function of hemopexin?
bind and transport heme to the liver
Low hemopexin indicates what?
Anemia
What is the main function of A1-antiprotease? Decreased activity leads to what?
Which allele is non-functional, M or Z?
Antiprotease activity in the lung
Pulmonary emphysema
Z allele is non-functional
Where is A1-AP synthesized? Irregularities can indicate what?
Synthesized by hepatocytes and can indicate liver disorders
Do gamma-globulins show immediate response/
No. Delayed response
A decrease in Albumin is normally accompanied by what?
An increase in A2-macros
An electrophoresis displays decreased albumin, increased A2-macros, and increased gamma-g's. What is the diagnosis?
Delayed response to infection.
Extremely high A2's on an electrophoresis indicate what?
Nephrotic syndrome/renal failure. A2's are too big to be filtered.