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24 Cards in this Set
- Front
- Back
Name two major Alpha-1 Globulins.
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A1-Antitrypsin
A-lipoprotein |
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Name three major Alpha-2 Globulins.
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A2-macroglobulin
Haptoglobin Ceruloplasmin |
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Name two major Beta-1 Globulins.
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Transferrin
B-lipoprotein |
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Name two major Beta-2 Globulins.
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Fibrinogen
C3 (complement) |
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What is the major class of Gamma globulins?
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Immunoglobulins
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Name two major functions of albumin.
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Transport (drugs, fatty acids, bilirubin)
Maintaining oncotic pressure |
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Name one cause of edema.
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Hypoalbuminemia
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What is analbuminemia? How is it compensated?
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Inherited hypoalbuminemia
Increased Alpha-2s |
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What binds retinol and thyroid hormone/
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Prealbumin
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B2-microglobulin, a subunit of HLA (Human Leukocyte Ag), is used to detect what/
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Renal failure
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Name two proteins used to detect renal failure/nephrotic syndrome.
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B2-Micro
A2-macro |
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Alpha-FP is used to detect what three sydromes?
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Spina bifida
Down's syndrome Liver cancer |
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What is the role of haptoglobin?
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Binding AB dimers of Hb, and transporting them to spleen for degradtion.
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Decreased haptoglobin is associated with what?
What about increase? |
Anemia
Hemolysis |
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Can haptoglobin bind myoglobin?
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No
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If tehre is blood in teh urine, but haptoglobin count is normal, where is the blood from?
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Mb/muscle tissue
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What is the function of hemopexin?
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bind and transport heme to the liver
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Low hemopexin indicates what?
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Anemia
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What is the main function of A1-antiprotease? Decreased activity leads to what?
Which allele is non-functional, M or Z? |
Antiprotease activity in the lung
Pulmonary emphysema Z allele is non-functional |
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Where is A1-AP synthesized? Irregularities can indicate what?
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Synthesized by hepatocytes and can indicate liver disorders
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Do gamma-globulins show immediate response/
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No. Delayed response
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A decrease in Albumin is normally accompanied by what?
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An increase in A2-macros
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An electrophoresis displays decreased albumin, increased A2-macros, and increased gamma-g's. What is the diagnosis?
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Delayed response to infection.
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Extremely high A2's on an electrophoresis indicate what?
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Nephrotic syndrome/renal failure. A2's are too big to be filtered.
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