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23 Cards in this Set

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Inhibitors of COX1/COX2 Activity
NSAIDS
COX2 Inhibitors
Cyclic Endoperoxides
Intermediates from AA
PGG2
PGH2
PGI2
endothelial of blood vessels
Activates adenylyl cyclase to increase cAMP
Decrease intracellular calcium
IP receptor
vasodilation (potent)
INHIBITS platelet aggregation
stimulates renin release
natriuresis
diuresis
TXA2
activates phosphatidylinositol metabolism
increased IP3 and intracellular Ca2+
platelets
TP receptor
vasoCONSTRICTION
platelet aggregation
bronchoCONSTRICTION
PGF2alpha
FP recep
Increases uterine tone
some broncho- and vasoCONSTRICTION
Increase aq humor outflow to decrease intraocular pressure
glaucoma
PGE2
EP2 recep
vasoDILATION
relaxes GI tone
bronchoDILATION
cytoprotective prostaglandin

EP3 recep
INHIBITS gastric acid secretion
INCREASES gastric mucus secretion
stimulation of pregnancy contractions
PGD2
DP recep
vasoDILATION
INHIBITS platelet agg
relax GI tone
relax uterine smooth muscle
Inflammation Prostaglandins
PGD2
PGE2
PGI2
Pain Prostaglandins
PGE2
PGI2
Fever Prostaglandins
PGE2
Platelet Activity
PGI2
increased cAMP levels
disaggregation

TXA2
increased IP3 levels
mobilization of intracellular Ca2+
Aggregation
COX1
TXA2
COX2
PGI2
Smooth Muscle Constrictor
TXA2
PGF2alpha
Smooth Muscle Dilator
PGE2
PGI2
GI
Stimulation of intestinal motility

Longitudinal muscles contract by PGE2 and PGF2alpha

Circular muscle
-contracted by PGF2alpha
-relaxed by PGE2
Uterine
increased tone and uterine contractions

Levels of PGE and PGF increase during labor

Potent oxytoxic action

Can terminate pregnancy at any stage!
Incs collagenase activity to soften cervix
Cytoprotection
PGE2 and PGI2
Inhibition of gastric acid secretion
Stimulation of mucus secretion
Increased bicarb secretion
Increased mucosal blood flow

enhance resistance of gastric mucosal cells to damage
accelerate ulcer healing
Renal Effects
Major products in kidney are PGE2 and PGI2
Protective mech
Maintain bp
Regulate renal fxn
Vasodilation
Increase glomerular filtration
Modulate renal blood flow
Inc medullary blood flow
Natriuretic
Block ADH eff to increase water clearance
Eye
PGF2alpha
increase aqueous humor outflow
decrease intraocular pressure
Open angle glaucoma
COX1 Inhibition
GI bleeding
TXA2 inhibition
platelet agg inhibition
COX2 inhibition
Stroke
MI
PGI2
platelet deagg inhibition
PGs Specific Effects
Inflammation
Pain
Fever
Platelet activity
Smooth muscle
GI
Reproductive actions
Renal effects
Eye