Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
23 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
Inhibitors of COX1/COX2 Activity
|
NSAIDS
COX2 Inhibitors |
|
|
|
Cyclic Endoperoxides
|
Intermediates from AA
PGG2 PGH2 |
|
|
|
PGI2
|
endothelial of blood vessels
Activates adenylyl cyclase to increase cAMP Decrease intracellular calcium IP receptor vasodilation (potent) INHIBITS platelet aggregation stimulates renin release natriuresis diuresis |
|
|
|
TXA2
|
activates phosphatidylinositol metabolism
increased IP3 and intracellular Ca2+ platelets TP receptor vasoCONSTRICTION platelet aggregation bronchoCONSTRICTION |
|
|
|
PGF2alpha
|
FP recep
Increases uterine tone some broncho- and vasoCONSTRICTION Increase aq humor outflow to decrease intraocular pressure glaucoma |
|
|
|
PGE2
|
EP2 recep
vasoDILATION relaxes GI tone bronchoDILATION cytoprotective prostaglandin EP3 recep INHIBITS gastric acid secretion INCREASES gastric mucus secretion stimulation of pregnancy contractions |
|
|
|
PGD2
|
DP recep
vasoDILATION INHIBITS platelet agg relax GI tone relax uterine smooth muscle |
|
|
|
Inflammation Prostaglandins
|
PGD2
PGE2 PGI2 |
|
|
|
Pain Prostaglandins
|
PGE2
PGI2 |
|
|
|
Fever Prostaglandins
|
PGE2
|
|
|
|
Platelet Activity
|
PGI2
increased cAMP levels disaggregation TXA2 increased IP3 levels mobilization of intracellular Ca2+ Aggregation |
|
|
|
COX1
|
TXA2
|
|
|
|
COX2
|
PGI2
|
|
|
|
Smooth Muscle Constrictor
|
TXA2
PGF2alpha |
|
|
|
Smooth Muscle Dilator
|
PGE2
PGI2 |
|
|
|
GI
|
Stimulation of intestinal motility
Longitudinal muscles contract by PGE2 and PGF2alpha Circular muscle -contracted by PGF2alpha -relaxed by PGE2 |
|
|
|
Uterine
|
increased tone and uterine contractions
Levels of PGE and PGF increase during labor Potent oxytoxic action Can terminate pregnancy at any stage! Incs collagenase activity to soften cervix |
|
|
|
Cytoprotection
|
PGE2 and PGI2
Inhibition of gastric acid secretion Stimulation of mucus secretion Increased bicarb secretion Increased mucosal blood flow enhance resistance of gastric mucosal cells to damage accelerate ulcer healing |
|
|
|
Renal Effects
|
Major products in kidney are PGE2 and PGI2
Protective mech Maintain bp Regulate renal fxn |
Vasodilation
Increase glomerular filtration Modulate renal blood flow Inc medullary blood flow Natriuretic Block ADH eff to increase water clearance |
|
|
Eye
|
PGF2alpha
increase aqueous humor outflow decrease intraocular pressure Open angle glaucoma |
|
|
|
COX1 Inhibition
|
GI bleeding
TXA2 inhibition platelet agg inhibition |
|
|
|
COX2 inhibition
|
Stroke
MI PGI2 platelet deagg inhibition |
|
|
|
PGs Specific Effects
|
Inflammation
Pain Fever Platelet activity Smooth muscle GI Reproductive actions Renal effects Eye |
|
