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9 Cards in this Set
- Front
- Back
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Anticoagulants
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Heparins Dalteparin Danaparoid Enoxaparin Heparin Direct thrombin inhibitors Bivalirudin Dabigatran Factor Xa inhibitors Apixaban Fondaparinux Rivaroxaban Other anticoagulants Warfarin |
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Antiplatelet drugs |
Glycoprotein IIb/IIIa inhibitors Abciximab Eptifibatide Tirofiban P2Y12 antagonists Clopidogrel Prasugrel Ticagrelor Other antiplatelet drugs Aspirin (antiplatelet) Dipyridamole |
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Thrombolytics
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Alteplase Reteplase Tenecteplase Urokinase |
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Other drugs affecting haemostasis |
Protamine -Combines with heparin to form a stable inactive complex, reversing its anticoagulant effect. Tranexamic acid -Inhibits breakdown of clots by blocking binding of plasminogen and plasmin to fibrin. Vitamin K -Inhibits breakdown of clots by blocking binding of plasminogen and plasmin to fibrin. |
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Drugs for heart failure
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Aldosterone antagonists Eplerenone Spironolactone Loop diuretics Bumetanide Ethacrynic acid Frusemide Sympathomimetics (cardiovascular) Adrenaline (cardiovascular) Dobutamine Dopamine Noradrenaline Other drugs for heart failure Milrinone |
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Drugs for angina
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Nitrates Glyceryl trinitrate Isosorbide dinitrate Isosorbide mononitrate Other antianginal drugs Ivabradine Nicorandil Perhexiline |
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Von WillebrandFactor
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-Large multimeric protein comprising subunits of 250 kDa each (2813AA) - Chromosome 12 -20% synthesised by megakaryocytes and stored in platelet α-granules -80% synthesised by endothelial cells and stored in cytoplasmic granules >Weibel-Paladebodies -Released under the influence of: a. stress and exercise b. adrenaline c. desmopressin -Secreted into circulation and into subendothelialspace |
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vWF functions |
Three functions: 1. platelet adhesion (GP Ib/V/IX) 2. platelet aggregation (GP IIb/IIIa) 3. carrier for Factor VIII |
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von Willebrand’s Disease |
-commonest inherited bleeding disorder clinical prevalence: 1:1000 -bleeding disorder involving von Willebrand Factor >mild bleedingfrom mucosal surfaces -defect may be: a. quantitative b. qualitative c. platelet receptor defect -may be: a. congenital(usual – autosomal dominant inheritence) b. acquired (rare – autoantibody)o |
