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11 Cards in this Set
- Front
- Back
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Osteoblasts and osteocytes are derived from what type of stem cell? What type of stem cell are osteoclasts derived from ? |
Mesenchymal stem cell Haematopoietic stem cells |
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Label the missing stages in bone remodeling? |
A: resorption B: reversal C: formation |
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How long does the remodeling phase last for? |
about 6 months |
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How long does the resorption phase last for? |
about 10-14 days |
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How long does the formation phase last for? |
about 150 days (5 months) |
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Which enzyme is abundant within osteoclasts and is frequently used as a biomarker of bone metabolism? |
Tartrate-Resistant Acid Phosphatase (TRAP) |
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Which are the main cells involved in bone metabolism which express osteprotegerin? |
osteoblasts and bone marrow stromal cells |
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What is the function of PU.1 |
Transcription factor required for the differentiation of early osteoclast precursors from haematopoietic cells |
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What shared function do the following have: Macrophage Colony Stimulating Factor (M-CSF) c-fos Nuclear Factor Kappa B (NFkB) Receptor Activator of Nuclear Factor Kappa B (RANK) RANK Ligand (RANKL) |
Promote the differentiation of committed osteoclast precursors into mature osteoclasts. |
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What is the role of osteoprotegerin in bone metabolism |
inhibits osteoclast formation and activity by binding to RANK-L - an activator of RANK. |
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Name two substances which osteoclasts use to resorp bone. What respective functions do each of these substances have? |
hydrochloric acid and proteolytic enzymes hydrochloric acid degrades hydroxyapatite, allowing proteolytic enzymes to degrade collagen and other bone matric proteins. |
