Primary Glomerulonephritides

Front 1

Postinfectious GN
(Clinical Presentation)

Back 1

1. Nephritic Syndrome

Front 2

Postinfectious GN
(Pathogenesis)

Back 2

1. Immune complex mediated (circulating or planted antigen)

Front 3

Postinfectious GN
(LM, FM, EM)

Back 3

1. Diffuse endocapillary proliferation with leukocytic infiltration
2. Granular IgG and C3 in GBM and mesangium
3. Subepithelial Bumps ("lumpy bumpy")

Front 4

Goodpasture Syndrome
(Clinical Presentation)

Back 4

1. RPGN - acute nephritis, proteinuria, ARF

Front 5

Goodpasture Syndrome
(Pathogenesis)

Back 5

1. Anti-GBM COL4-A3 antigen

Front 6

Goodpasture Syndrome
(LM, FM, EM)

Back 6

1. Extracapillary proliferation with crescents and necrosis
2. Linear IgG and C3, fibrin in crescents
3. No deposits, with GBM disruptions and fibrin (not sure about GBM disruptions and fibrin)

Front 7

Chronic GN
(Clinical Presentation)

Back 7

1. Chronic Renal Failure - Azotemia -> uremia progressing for months to years

Front 8

Chronic GN
(Pathogenesis)

Back 8

1. Variable...

Front 9

Chronic GN
(LM, FM, EM)

Back 9

1. Hyalinized glomeruli
2. Granular or negative
3. N/A

Front 10

Membranous GN
(Clinical Presentation)

Back 10

1. Nephrotic Presentation

Front 11

Membranous GN
(Pathogenesis)

Back 11

1. In situ immune complex formation (with unknown antigens)

Front 12

Membranous GN
(LM, FM, EM)

Back 12

1. Diffuse capillary wall thickening
2. Granular IgG and C3, diffuse
3. Subepithelial deposits

Front 13

Minimal Change Disease
(Clinical Presentation)0

Back 13

1. Nephrotic Syndrome

Front 14

Minimal Change Disease
(Pathogenesis)

Back 14

1. Unknown, podocyte injury

Front 15

Minimal Change Disease
(LM, FM, EM)

Back 15

1. Normal, maybe some lipid in tubules
2. Negative
3. Effacement of foot processes, no deposits

Front 16

Focal Segmental Glomerulosclerosis
(Clinical Presentation)

Back 16

1. Nephrotic Syndrome (sometimes with non-nephrotic proteinuria)

Front 17

Focal Segmental Glomerulosclerosis
(Pathogenesis)

Back 17

1. Largely unknown, nephropathy, podocyte injury - Plasma factor?

Front 18

Focal Segmental Glomerulosclerosis
(LM, FM, EM)

Back 18

1. Focal and segmental sclerosis and hyalinosis
2. Focal IgM and C3
3. Loss of foot processes, epithelial denudation

Front 19

Membranoproliferative Glomerulonephritis - Type I
(Clinical Presentation)

Back 19

1. Nephritic or Nephrotic syndrome

Front 20

Membranoproliferative Glomerulonephritis - Type I
(Pathogenesis)

Back 20

1. Immune complex

Front 21

Membranoproliferative Glomerulonephritis - Type I
(LM, FM, IM)

Back 21

1. Mesangial and endocapillary proliferation with GBM splitting and thickening
2. IgG and C3, or C1q and C4
3. Subendothelial "tram-track" deposits

Front 22

Membranoproliferative Glomerulonephritis - Type II
(Clinical Presentation)

Back 22

1. Hematuria, CRF

Front 23

Membranoproliferative Glomerulonephritis - Type II
(Pathogenesis)

Back 23

1. Autoantibody and alternative compliment pathway

Front 24

Membranoproliferative Glomerulonephritis - Type II
(LM, FM, EM)

Back 24

1. Mesangial and endocapillary proliferation with GBM thickening and splitting
2. C3 with or without IgG, C1q or C4
3. Dense deposits

Front 25

IgA Nephropathy
(Clinical Presentation)

Back 25

1. Recurrent hematuria or proteinuria

Front 26

IgA Nephropathy
(Pathogenesis)

Back 26

1. Unknown

Front 27

IgA Nephropathy
(LM, FM, EM)

Back 27

1. Focal mesangial proliferative glomerulonephritis with mesangial widening
2. IgA in mesangium, possibly with IgG, IgM and C3
3. Mesangial and paramesangial dense deposits