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14 Cards in this Set
- Front
- Back
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If I told you that a test was done on serum testosterone and serum LH and FSH and they were all low, then where is the problem? What if only testosterone was low, but LH/FSH were high? |
problem upstream of TSH thyroid gland problem |
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what would happen in a test of function if ACTH is lacking? |
adrenal gland will suffer / cortisol will not respond well in test |
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where are OT and VP made origin? |
neurosecretory cells in hyp nuclei peptide hormones, all vertebrates have em, gene duplication |
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main function of VP |
osmoregulation and pressure regulation |
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main function of OT |
uterine contraction and milk ejection, mother-offspring bonding (maternal behaviour / NT) males: sperm transport in ejaculation |
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feedback loop of OT? |
(+) feedback in breastfeeding: 1. suckling relayed by mechanoreceptors to hyp, 2. secretion of OT in pulses from post pit, 3. OT binds mammary glands, stim milk let down |
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role of OT in stress response |
inhib CRH/VP mediated ACTH release |
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OT receptor signalling |
GPCR (G-alpha-q) --> stim PLC, generates IP3 and DAG - smooth muscle: act on myosin light-chain kinase activity (contraction for milk) - neurosec cells: increase Ca2+ means increase firing and NT release --> hugs are good! |
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VP role in osmoregulation |
VR on renal collecting duct (a GPCR G-alpha-s) - activates PKA to stim transcription of aquaporin-2 (more aquaporin) also stim NaCl and urea reabsorption |
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role of VP in BP |
binds VR in vessels to increase pressure by vascular constriction (stim PLC, same path that stim smooth muscle contraction) |
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role of VP in stress response
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regulates secretion of ACTH (acts synergistically w/ CRH to mediate ACTH release) |
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vasopressin deficiency disease characterized by |
diabetes insipidus - large volumes of dilute urine - eff'd up ion balance, excessive thirst/dehydration |
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diabetes insipidus - causes? |
hypothalamic: trauma, tumor, surgery, mutation in VP gene nephrogenic: mut in VR receptor in kidney, aquaporin defect gestational: during preg when metabolism of VP is increased |
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pair bonding in monogamous prairie vole is stim by? |
female: oxytocin released during mating (DA) male: VP stim pair bonding, aggression towards rivals, paternal instincts |
