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32 Cards in this Set
- Front
- Back
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What is the most common TORCH infection?
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CMV: 80%
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clinical Sx of CMV in infected mother?
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increased fatigue, flu like sxs in the 1st trimester
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permanent Sxs of CMV?
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Hearing loss
Seizures |
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What separates CMV from EBV?
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Mono is heterophile negative
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Transmission of CMV (5)
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droplets
fecal oral transplacental breast milk STD |
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Diagnosis of CMV?
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IgM antibody on TORCH panel
Buffy Coat Histo: Owl's Eyes |
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Pathology of CMV?
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Affects lymphocytes, lies latent in killer cells
Stops MHC I and MHC II secretes IL-10, decreases TH1 response, decreases CMI |
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What are the Sxs of CMV in an infant?
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Small head, erethematous rash, icterus, hepatosplenomegaly, sensorineural hearing loss
Imaging: periventricular calcifications Mullberry muffin rash |
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HIV patient with a seizure, recent history of severe headache, lymphadenopathy, papillidema, and loves cats
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Toxoplasmosis
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cresent-shapped trophozoite within macrophages
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toxoplasmosis
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cysts ingested from undercooked meat or from cats
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toxoplasmosis
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pathogenesis of toxoplasmosis
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cysts ingested --> small intestine and release invasive form which penetrate intestinal wall and then disseminate or get taken up by macrophages
host response contains the infection in tissue, and invasive form becomes dormant. If host becomes immuno compromised --> encephalitis |
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Microcephaly, intracerebral calcification, chorioretinitis and mental retardation in a kid
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congenital toxoplasmosis
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Nodular enhancements or Ring mass lesion on MRI
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toxoplasmosis
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What is the MCC of encephalitis in HIV?
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Toxoplasmosis
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IgB, IgD spikes
glycoprotein coat Nucleocapsid DS DNA core |
Herpes simplex virus
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25 year old homosexual male with painful skin rash in the perianal area, hx of unprotected sex with multiple partners, vesicular rash in clusters on erethematous base
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herpes
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pathogenesis of herpes
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primary infection goes to epithelial cells, causes lesions, enters nerves, traves retrograde and uncoats and tethers itself there. Reactivates in S2-S5 dermatome
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what causes reactivation of herpes?
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stress, disease
when the neuron becomes metabolically active, the HSV activates |
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Why cant the body take care of HSV primary infections?
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it moves into neurons so fast it avoids the primary immune response on initial infection.
The body will make antibody and this lessens the recurrent infections |
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how long do sxs last in HSV?
How long does the virus shed in HSV? |
symptoms last from 12-20 days
Shedding lasts 12 days and starts 2 days before lesions show |
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neonatal herpes, 3 contidions
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1) SEM: skin, eyes, mouth
2) encephalitis/ CNS 3) disseminated |
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diagnosis of herpes
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Tzank smear
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gram positive bacilli, motile via tumbling motility
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Listeria Monocytogenes
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GI symptoms with fever and seizure
Labs show CSF with decreased glucose, |
Listeria Monocytogenes
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2 month old with fever, convulsions, irritability, poor eating, widespread rash and stiff neck
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Listeria Monocytogenes
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Pathobiology of Listeria Monocytogenes
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heat resistant listeria survive poor pasturization --> GI --> phagocytes --> blood --> neural tissue --> meningitis
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The only gram positive with endotoxin
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Listeria Monocytogenes
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Why should preggos avoid cold cuts and soft cheeses?
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Listeria Monocytogenes
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PDA, cataracts, deafness, and blueberry muffin rash. mom had flu like sxs in 1st trimester
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Rubella
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#1 cause of neonatal sepsis
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Group B strep
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MC cause of meningitis in 1st month of life?
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Group B strep
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