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7 Cards in this Set
- Front
- Back
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What are the 2 strains of polyomaviruses that affect humans? Where do they typically reside?
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1.BK - kidney
2.JC - nervous tissue |
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Of which family are the polyomaviruses a subgroup?
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Papovaviruses.
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Describe the structure of the polyomaviruses.
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*naked - no lipid envelope
*icosohedral capsid *dsDNA genome |
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Where does replication of polyomaviruses occur? Do the viruses use host machinery or viral-encoded enzymes?
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Replication occurs in the nucleus of the host cell and is performed by host DNA-dependent DNA pol.
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Are polyomaviruses common? How do they generally present in immunocompetent hosts?
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They are ubiquitous and usually present as cryptic, asymptomatic infections.
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How are polyomaviruses transmitted? Where is their point of entry?
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They are transmitted via the respiratory route and enter at the oropharynx.
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With what disease is JC virus often associated?
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Progressive multifocal leukoencephalopathy.
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